ArticleLife (Basel, Switzerland)2024
Clinical Efficacy and Safety of Ultrasound-Guided Injection with Low-Molecular-Weight Peptides from Hydrolyzed Collagen in Patients with Partial Supraspinatus Tendon Tears: A Pilot Study.
Article in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Ultrasound-Guided Collagen Peptides Injections Combined with Focused Extracorporeal Shockwave Therapy and Therapeutic Exercise in Chronic Partial Common Extensor Tendon Tears at Elbow Lateral Epicondyle: A Retrospective Case Series.Life (Basel, Switzerland) · 2026Article
- Musculoskeletal Ultrasound and Protein-Based Hydrogels: Novel Approaches for the Diagnosis and Treatment of Sports Injuries.Polymers · 2026Review
- Clinical efficacy and safety of ultrasound-guided injection with low-molecular-weight peptides from hydrolyzed collagen in patients with first carpometacarpal joint osteoarthritis.Frontiers in medicine · 2026Article
- Clinical evidence for low-molecular-weight collagen peptides in tendon and ligament tears: a systematic review with narrative synthesis.Frontiers in medicine · 2026Review
- Collagen injections versus dry needling in the treatment of chronic supraspinatus tendinopathy: a randomized controlled trial.Frontiers in surgery · 2026Article
- Efficacy of Ultrasound-Guided Injections of Type I Collagen-Based Medical Device for Greater Trochanteric Pain Syndrome: A Pilot Study.Life (Basel, Switzerland) · 2025Article
- Collagen Injections for Rotator Cuff Diseases: A Systematic Review.Clinics and practice · 2025Review
- Hydrolyzed Marine Collagen: Emerging Evidence of Benefits via the Oral Route - Review and Insights for Medical Aesthetics Practitioners.Clinical, cosmetic and investigational dermatology · 2025Review
- Ultrasound Guided Injection of Collagen for Elbow Lateral Epicondylitis - A Pilot Study.Current health sciences journalArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study evaluates the clinical efficacy and safety of two ultrasound (US)-guided injections of a 5 mg/1 mL low-molecular-weight peptide (LWP) solution derived from hydrolyzed bovine collagen in patients with supraspinatus partial tendon tears.
methodsA total of 21 patients with symptomatic partial tears of the supraspinatus tendon, detected by US, were consecutively enrolled and received one injection at a baseline visit (T0) and one after two weeks (T1). The primary outcome measure was the visual analogue scale (VAS) for pain. Secondary outcomes were the shoulder pain and disability index (SPADI) total score and the safety of LWP injections. Patients were examined at baseline (T0), at a week 2 follow-up visit (T1), and at a week 12 follow-up visit (T2).
resultsA statistically significant improvement was found for both VAS pain and SPADI total scores, between T0 and T2 visits. US-guided injections were well tolerated and, apart from one patient with a progression of a tendon tear, no adverse events were recorded.
conclusionsIntratendinous tear US-guided injection therapy with an LWP solution was found to be safe and effective in improving both pain and shoulder function at a 12-week follow-up visit. The present pilot study should be considered the first step justifying a larger confirmatory investigation.
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