ArticleLife (Basel, Switzerland)2024
Niemann-Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study.
Ryuk Jun Kwon, Ho Jun Kim, Young-Shin Lee, Hye Sun Lee, Sang Yeoup Lee, Eun-Ju Park, Youngin Lee, Sae Rom Lee, Jung-In Choi, Soo Min Son and 7 more
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In one paragraphArticle in Life (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
17 authors.
Ryuk Jun KwonFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0001-7757-7412 Ho Jun KimFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Young-Shin LeeFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Hye Sun LeeFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Sang Yeoup LeeFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0002-3585-9910 Eun-Ju ParkFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0003-2415-8243 Youngin LeeFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0003-0141-7484 Sae Rom LeeFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.
Jung-In ChoiFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0003-3832-3393 Soo Min SonFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0002-0165-7480 Jeong Gyu LeeDepartment of Family Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.
Yu Hyeon YiDepartment of Family Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0002-1786-2737 Young Jin TakDepartment of Family Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.
Seung-Hun LeeDepartment of Family Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0002-0976-8708 Gyu Lee KimDepartment of Family Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.ORCID 0000-0003-2825-0629 Young Jin RaDepartment of Family Medicine, Pusan National University School of Medicine, Yangsan 50612, Republic of Korea.
Young Hye ChoFamily Medicine Clinic and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea.ORCID 0000-0003-2176-6227 Funding
National Research Foundation of Korea (NRF) No. NRF-2022R1F1A1074769; R.J.K.
6 · The paper itselfAbstract
backgroundRenal cell carcinoma (RCC) is a highly aggressive malignancy accounting for the majority of kidney cancers. Despite recent advancements in therapeutic options, the prognosis for advanced-stage RCC remains poor. Niemann-Pick C1-Like 1 (NPC1L1) plays a crucial role in cholesterol absorption and has been implicated in cancer progression across various cancers. However, its expression patterns and prognostic significance in RCC remain unclear.
methodsIn this study, NPC1L1 expression in normal and RCC tissues, including subtypes, was compared using TCGA, GEPIA2, and The Human Protein Atlas. Clinical correlations were assessed, and the impact of
resultsNPC1L1 expression was significantly lower in RCC tissues compared to normal tissues, particularly in the clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC) subtypes, but increased in advanced tumor stages. Higher
conclusionsThis study determines NPC1L1 as an independent prognostic indicator in RCC, with higher expression associated with poor survival outcomes. These findings suggest that NPC1L1 could serve as a valuable marker for identifying high-risk RCC patients. Further research is required to investigate the molecular mechanisms underlying the role of NPC1L1 in RCC progression.
Indexed as
cholesterolezetimibelipid metabolismNPC1L1prognostic markerrenal cell carcinoma
Identifiers
PMID39598242
PMCPMC11595514
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