Evidence map›Paper›PMID 39598454›Full record

ArticlePharmaceuticals (Basel, Switzerland)2024

Structure of a Cyclic Peptide as an Inhibitor of

Filia Stephanie, Usman Sumo Friend Tambunan, Krzysztof Kuczera, Teruna J Siahaan

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Role of stereochemistry on electron transport in peptides.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Article
  4. Peptide-Based Strategies AgainstPharmaceuticals (Basel, Switzerland) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Filia StephanieDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.
Usman Sumo Friend TambunanDepartment of Chemistry, University of Indonesia, Depok 16424, Indonesia.ORCID 0000-0001-6025-2195
Krzysztof KuczeraDepartment of Chemistry, The University of Kansas, Lawrence, KS 66045, USA.ORCID 0000-0003-2358-1349
Teruna J SiahaanDepartment of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS 66047, USA.ORCID 0000-0001-7250-0627

Funding

Synthetic Chemical Biology CoreP20GM113117 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI HEFTY, P SCOTT · 2016 to 2025
$23.9M
Reshaping ApoE4 and Alzheimer's Brains with ApoE2R01AG071682 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI TERUNA J. SIAHAAN, Liqin Zhao · 2022 to 2026
$3.4M
A Novel Method to Enhance Drug Delivery to the BrainR01AG082273 · NIA · UNIVERSITY OF KANSAS LAWRENCE · PI KRZYSZTOF KUCZERA, TERUNA J. SIAHAAN · 2024 to 2026
$1.4M
Avance II 500 High Performance Digital NMR Spectrometer SystemS10RR024664 · NCRR · UNIVERSITY OF KANSAS LAWRENCE · PI VANDERVELDE, DAVID G · 2007 to 2007
$468k
Indonesian Ministry of Research, Technology, and Higher Education through PMDSU NKB-3037/UN2.R3.1/HKP.05.00/2019NIA NIH HHS R01 AG071682NIA NIH HHS R01 AG082273NIGMS NIH HHS P20 GM113117NIH HHS R01-AG071682NIH Shared Instrumentation Grant S10RR024664NSF Major Research Instrumentation Award 1625923Pilot Grant, COBRE Chemical Biology Infectious Disease P20-GM113117
6 · The paper itself

Abstract

BACKGROUND AND

objectivesA novel antitubercular cyclic peptide, Cyclo(1,6)-Ac-CLYHFC-NH

methodsHere, the solution structure of Cyclo(1,6)-Ac-CLYHFC-NH

resultsAll protons of Cyclo(1,6)-Ac-CLYHFC-NH

conclusionsThe NMR-restrained MD simulations showed several low-energy conformations that were congruent with the NMR data. Finally, the conformation of this peptide will be used to design derivatives that can better inhibit RNAP activity.

Indexed as

cyclic peptide conformationmolecular dynamics simulationmRNA polymerase inhibitorMycobacterium tuberculosisnuclear magnetic resonance

Identifiers

PMID39598454
PMCPMC11597662

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.