Evidence map›Paper›PMID 39598515›Full record

ReviewPharmaceutics2024

Pharmacological Treatment of Interstitial Lung Diseases: A Novel Landscape for Inhaled Agents.

Vito D'Agnano, Fabio Perrotta, Ramona Fomez, Valerio Maria Carrozzo, Angela Schiattarella, Stefano Sanduzzi Zamparelli, Raffaella Pagliaro, Andrea Bianco, Domenica Francesca Mariniello

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vito D'AgnanoDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
Fabio PerrottaDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.ORCID 0000-0002-7223-7037
Ramona FomezDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
Valerio Maria CarrozzoDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
Angela SchiattarellaDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.
Stefano Sanduzzi ZamparelliDivision of Pneumology, A. Cardarelli Hospital, 80131 Naples, Italy.
Raffaella PagliaroDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.ORCID 0009-0006-2902-3558
Andrea BiancoDepartment of Translational Medical Sciences, University of Campania L. Vanvitelli, 80131 Naples, Italy.ORCID 0000-0002-4692-5901
Domenica Francesca MarinielloUOC Pneumotisiologia Federico II, A.O.R.N. Monaldi-Cotugno-CTO Piazzale Ettore Ruggieri, 80131 Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interstitial lung diseases (ILDs) encompass a heterogeneous group of over 200 disorders that require individualized treatment. Antifibrotic agents, such as nintedanib and pirfenidone, have remarkably revolutionized the treatment landscape of patients with idiopathic pulmonary fibrosis (IPF). Moreover, the approval of nintedanib has also expanded the therapeutic options for patients with progressive pulmonary fibrosis other than IPF. However, despite recent advances, current therapeutic strategies based on antifibrotic agents and/or immunomodulation are associated with non-negligible side effects. Therefore, several studies have explored the inhalation route aiming to spread higher local concentrations while limiting systemic toxicity. In this review, we examined the currently available literature about preclinical and clinical studies testing the efficacy and safety of inhalation-based antifibrotics, immunomodulatory agents, antioxidants, mucolytics, bronchodilators, and vasodilator agents in ILDs.

Indexed as

antifibroticsantioxidantsbronchodilatorscorticosteroidsidiopathic pulmonary fibrosisinhaled agentsinterstitial lung diseases

Identifiers

PMID39598515
PMCPMC11597590

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.