Evidence map›Paper›PMID 39598561›Full record

ArticlePharmaceutics2024

Cord Blood Platelet Lysate-Loaded Thermo-Sensitive Hydrogels for Potential Treatment of Chronic Skin Wounds.

Arianna Grivet-Brancot, Marianna Buscemi, Gianluca Ciardelli, Simona Bronco, Susanna Sartori, Claudio Cassino, Tamer Al Kayal, Paola Losi, Giorgio Soldani, Monica Boffito

Abstract read
In one paragraph

Article in Pharmaceutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arianna Grivet-BrancotInstitute for Chemical-Physical Processes, National Research Council, 56124 Pisa, Italy.
Marianna BuscemiInstitute of Clinical Physiology, National Research Council, Massa, 56124 Pisa, Italy.
Gianluca CiardelliInstitute for Chemical-Physical Processes, National Research Council, 56124 Pisa, Italy.ORCID 0000-0003-0199-1427
Simona BroncoInstitute for Chemical-Physical Processes, National Research Council, 56124 Pisa, Italy.ORCID 0000-0002-4832-7569
Susanna SartoriDepartment of Mechanical and Aerospace Engineering, Politecnico di Torino, 10129 Torino, Italy.ORCID 0000-0001-6742-0657
Claudio CassinoDepartment of Science and Technological Innovation, Università del Piemonte Orientale, 15121 Alessandria, Italy.ORCID 0000-0002-7785-2717
Tamer Al KayalInstitute of Clinical Physiology, National Research Council, Massa, 56124 Pisa, Italy.
Paola LosiInstitute of Clinical Physiology, National Research Council, Massa, 56124 Pisa, Italy.ORCID 0000-0002-1350-8626
Giorgio SoldaniInstitute of Clinical Physiology, National Research Council, Massa, 56124 Pisa, Italy.
Monica BoffitoInstitute for Chemical-Physical Processes, National Research Council, 56124 Pisa, Italy.ORCID 0000-0001-7637-2001

Funding

Fondazione Pisa PREVISION "Prognostic evaluation of the use of three-dimensional bioactive scaffolds and injectable gels for the treatment of chronic lesions of the skin by means of new biomedical imaging technologies"
6 · The paper itself

Abstract

BACKGROUND/

objectivesChronic skin wounds (CSWs) are a worldwide healthcare problem with relevant impacts on both patients and healthcare systems. In this context, innovative treatments are needed to improve tissue repair and patient recovery and quality of life. Cord blood platelet lysate (CB-PL) holds great promise in CSW treatment thanks to its high growth factors and signal molecule content. In this work, thermo-sensitive hydrogels based on an amphiphilic poly(ether urethane) (PEU) were developed as CB-PL carriers for CSW treatment.

methodsA Poloxamer 407

resultsPEU aqueous solutions with concentrations in the range 10-15%

conclusionsThe developed hydrogels represent promising tools for CSW treatment, with tunable gelation properties and residence time and the ability to encapsulate and deliver active biomolecules with sustained and controlled kinetics.

Indexed as

chronic skin woundshydrogelsplatelet lysate

Identifiers

PMID39598561
PMCPMC11597581

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.