Evidence map›Paper›PMID 39598630›Full record

ArticleMolecules (Basel, Switzerland)2024

Amphetamine Derivatives as Potent Central Nervous System Multitarget SERT/NET/H

Quxiang Li, Lili Ren, Dongli Wang, Junyong Luo, Changda Xu, Jian Feng, Yufan Qiu, Xiangqing Xu, Guoguang Chen

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Quxiang LiSchool of Pharmacy, Nanjing Tech University, 30th South Puzhu Road, Nanjing 211816, China.ORCID 0009-0006-7662-6319
Lili RenSchool of Pharmacy, Nanjing Tech University, 30th South Puzhu Road, Nanjing 211816, China.ORCID 0000-0001-6423-9625
Dongli WangJiangsu Key Laboratory of Central Nervous System Drug Research and Development, Institute of Pharmaceutical Research, Jiangsu Nhwa Pharmaceutical Co., Ltd., Xuzhou 221116, China.ORCID 0000-0002-5038-6218
Junyong LuoSchool of Pharmacy, Nanjing Tech University, 30th South Puzhu Road, Nanjing 211816, China.ORCID 0009-0006-5669-9510
Changda XuJiangsu Key Laboratory of Central Nervous System Drug Research and Development, Institute of Pharmaceutical Research, Jiangsu Nhwa Pharmaceutical Co., Ltd., Xuzhou 221116, China.ORCID 0009-0005-9083-1987
Jian FengJiangsu Key Laboratory of Central Nervous System Drug Research and Development, Institute of Pharmaceutical Research, Jiangsu Nhwa Pharmaceutical Co., Ltd., Xuzhou 221116, China.ORCID 0009-0002-3312-0343
Yufan QiuPharmaron Beijing Co., Ltd., 6 Taihe Road, BDA, Beijing 100176, China.ORCID 0009-0007-0584-9141
Xiangqing XuJiangsu Key Laboratory of Central Nervous System Drug Research and Development, Institute of Pharmaceutical Research, Jiangsu Nhwa Pharmaceutical Co., Ltd., Xuzhou 221116, China.ORCID 0000-0003-3778-0824
Guoguang ChenSchool of Pharmacy, Nanjing Tech University, 30th South Puzhu Road, Nanjing 211816, China.

Funding

National Science and Technology Major Project (2017ZX0931057), Jiangsu key R&D plan (BE2019738), National Key R&D Program of China (2023YFF0723400) and Jiangsu Key Laboratory of Central Nervous System Drug Research and Development (BM2019004) 2017ZX0931057,BE2019738,2023YFF0723400,BM2019004
6 · The paper itself

Abstract

In this research, a variety of novel amphetamine derivatives were synthesized and assessed for their potential as multifaceted antidepressant agents. Among these compounds, compound

Indexed as

Antidepressive AgentsMolecular Docking SimulationReceptors, Histamine H3Serotonin Plasma Membrane Transport ProteinsAmphetamineAmphetaminesAnimalsCentral Nervous SystemHumansMaleMiceNorepinephrine Plasma Membrane Transport ProteinsRatsStructure-Activity RelationshipAmphetamineAmphetaminesAntidepressive AgentsNorepinephrine Plasma Membrane Transport ProteinsReceptors, Histamine H3Serotonin Plasma Membrane Transport Proteinsamphetamineantidepressantmolecular dockingmultitarget

Identifiers

PMID39598630
PMCPMC11870037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.