Evidence map›Paper›PMID 39598662›Full record

ArticleMolecules (Basel, Switzerland)2024

Phytochemical Analysis and Biological Evaluation of Carob Leaf (

Themistoklis Venianakis, Nikolaos Parisis, Atalanti Christou, Vlasios Goulas, Nikolaos Nikoloudakis, George Botsaris, Tjaša Goričan, Simona Golič Grdadolnik, Andreas G Tzakos, Ioannis P Gerothanassis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Themistoklis VenianakisSection of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
Nikolaos ParisisSection of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0003-1473-7970
Atalanti ChristouDepartment of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, 3603 Lemesos, Cyprus.ORCID 0000-0003-2130-6538
Vlasios GoulasDepartment of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, 3603 Lemesos, Cyprus.ORCID 0000-0001-7527-1559
Nikolaos NikoloudakisDepartment of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, 3603 Lemesos, Cyprus.ORCID 0000-0002-3935-8443
George BotsarisDepartment of Agricultural Sciences, Biotechnology and Food Science, Cyprus University of Technology, 3603 Lemesos, Cyprus.ORCID 0000-0003-3197-6535
Tjaša GoričanLaboratory for Molecular Structural Dynamics, National Institute of Chemistry, Theory Department, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.ORCID 0009-0000-7736-7941
Simona Golič GrdadolnikLaboratory for Molecular Structural Dynamics, National Institute of Chemistry, Theory Department, Hajdrihova 19, SI-1000 Ljubljana, Slovenia.ORCID 0000-0002-0873-9593
Andreas G TzakosSection of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0001-6391-0288
Ioannis P GerothanassisSection of Organic Chemistry and Biochemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-3745-9902

Funding

Operational Programme "Competitiveness, Entrepreneurship and Innovation MIS 5047291Research & Innovation Foundation Cyprus EXCELLENCE/0421/0205Slovenian Research and Innovation Agency J1-4400
6 · The paper itself

Abstract

Carob leaves have gained attention for their bioactive properties and traditional medicinal uses, including as treatment for diabetes, digestive disorders, and microbial infections. The aim of this study was to explore the phytochemical composition of carob leaf acetone extracts using advanced spectroscopic techniques. The combined use of heteronuclear nuclear magnetic resonance (NMR) experiments with 1D selective nuclear Overhauser effect spectroscopy (NOESY) offers detailed structural insights and enables the direct identification and quantification of key bioactive constituents in carob leaf extract. In particular, the NMR and mass spectrometry techniques revealed the presence of myricitrin as a predominant flavonoid, as well as a variety of glycosylated derivatives of myricetin and quercetin, in acetone extract. Furthermore, siliquapyranone and related gallotannins are essential constituents of the extract. The potent inhibitory effects of the carob leaf extract on

Indexed as

Anti-Bacterial AgentsFlavonoidsMagnetic Resonance SpectroscopyMass SpectrometryPhytochemicalsPlant ExtractsPlant LeavesStaphylococcus aureusMicrobial Sensitivity TestsPlant GumsAnti-Bacterial AgentsFlavonoidsmyricetinmyricitrinPhytochemicalsPlant ExtractsPlant Gumsantimicrobial activitycarbohydrate digestive enzyme inhibitioncarob leafflavonoidsgalloyl derivativesmass spectrometrymyricetinNMR spectroscopy

Identifiers

PMID39598662
PMCPMC11596379

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.