Evidence map›Paper›PMID 39599650›Full record

ArticleNutrients2024

Effect of the Intake of Solid Block Dairy Products Like Cheese on Serum Uric Acid in Children: A Preliminary Mechanistic Investigation.

Zhongting Lu, Zhenchuang Tang, Xin Guo, Lei Liu, Xuemei Cheng, Lianlong Yu, Guangyan Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhongting LuSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.ORCID 0009-0004-4873-1635
Zhenchuang TangInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.
Xin GuoSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Lei LiuShandong Center for Disease Control and Prevention, Jinan 250014, China.
Xuemei ChengShandong Center for Disease Control and Prevention, Jinan 250014, China.
Lianlong YuShandong Center for Disease Control and Prevention, Jinan 250014, China.ORCID 0000-0002-6631-5254
Guangyan ChengInstitute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing 100081, China.

Funding

J.W. and Z.T. 2022YFD1301005L.Y. 2020Q041L.Y. ZR2023QH157X.G. ZR2023MH140
6 · The paper itself

Abstract

objectiveThis study aimed to investigate the relationship between the intake of solid block dairy products like cheese and serum uric acid levels, along with its potential physiological mechanisms.

methodsData for our study were obtained from the Chinese Children and Lactating Women Nutrition and Health Surveillance. Generalized linear models and restricted cubic splines were employed to analyze the relationship between the intake of solid block dairy products like cheese and serum uric acid levels. Two-sample Mendelian randomization (TSMR) analysis was conducted to infer causality, based on a large sample size and robust methodology. Gene Ontology (GO) enrichment analysis was also performed to identify potential biological pathways.

resultsAmong all types of dairy products, a significant negative association with serum uric acid levels was observed only for the intake of solid block dairy products like cheese, regardless of covariate adjustment (β = -0.182,

conclusionsThe intake of solid block dairy products like cheese was found to result in decreased levels of serum uric acid, with potential mechanisms involving the JAK-STAT signaling pathway and the regulation of autophagy.

Indexed as

CheeseUric AcidChildChild, PreschoolChinaDairy ProductsDietFemaleHumansMaleMendelian Randomization AnalysisUric Acidcheesechildren and adolescentsMendelian randomizationserum uric acid levelssolid block dairy products

Identifiers

PMID39599650
PMCPMC11597038

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.