SynthesisNutrients2024
Mediterranean Diet in Older Adults: Cardiovascular Outcomes and Mortality from Observational and Interventional Studies-A Systematic Review and Meta-Analysis.
Synthesis in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Healthy dietary pattern and risk of rheumatoid arthritis: A systematic review and meta-analysis.Seminars in arthritis and rheumatism · 2025Pooled it
- Biological signature of dietary patterns in older adults: findings from a population-based study.BMC medicine · 2026Article
- The Role of the Gut Microbiome in the Relationship Between the Mediterranean Diet and Cardiovascular Disease Risk.Current atherosclerosis reports · 2026Review
- Validation and cultural adaptation of the pregnancy-adapted Mediterranean Diet Adherence Screener (ITpreg-MEDAS) in Italian pregnant women.European journal of nutrition · 2026Article
- Article
- Observational
- Association Between Food Security Status and Adherence to Mediterranean Diet Among Adults in Saudi Arabia: A Cross-Sectional Study.Foods (Basel, Switzerland) · 2026Article
- Dietary Polyphenols (Flavonoids) Derived from Plants for Use in Therapeutic Health: Antioxidant Performance, ROS, Molecular Mechanisms, and Bioavailability Limitations.International journal of molecular sciences · 2026Review
- Longevity, Centenarians, and Lifestyle: Any ''Tips'' to Live Longer?Current nutrition reports · 2026Review
- Adherence to the Mediterranean diet and incident cardiovascular outcomes among older adults.Frontiers in nutrition · 2026Article
- Cross-country variability in Mediterranean lifestyle adherence and its psychosocial and behavioural correlates: insights from the MEDIET4ALL project across 10 Mediterranean and neighboring countries.Frontiers in nutrition · 2026Article
- Effect of a multicomponent intervention on adherence to the Mediterranean diet in older adults: a randomized controlled trial.Frontiers in nutrition · 2026Article
- The Mediterranean diet and cardiovascular disease.Cardiovascular research · 2025Review
- Central Adiposity Assessed with Body Roundness Index and Mortality: The Seguimiento Universidad de Navarra Prospective Cohort.Geriatrics (Basel, Switzerland) · 2025Article
- Adherence to Three Mediterranean Dietary Indexes and All-Cause, Cardiovascular, and Cancer Mortality in an Older Mediterranean Population.Nutrients · 2025Article
- Dietary Habits and Obesity in Middle-Aged and Elderly Europeans-The Survey of Health, Ageing, and Retirement in Europe (SHARE).Nutrients · 2025Article
- Longitudinal effects of diet quality on healthy aging - Focus on cardiometabolic health: findings from the Canadian longitudinal study on aging (CLSA).Aging clinical and experimental research · 2025Article
- Observational
- Mediterranean diet adherence and tirzepatide: real-world evidence on adiposity indices and insulin resistance beyond weight loss.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesthere is conflicting evidence on the role of the Mediterranean Diet (MD) in reducing the risk of long-term outcomes in older adults. The aim of our study was to assess the effectiveness of high adherence to MD in reducing all-cause mortality and cardiovascular outcomes among older adults.
methodsPubMed database was searched up to 31 May 2023. We included randomized controlled trials (RCT) and cohort studies in the English language which evaluated the Mediterranean diet's adherence to exposure on a population with a mean age > 60 years. The main outcomes were cardiovascular fatal and non-fatal events, and all-cause mortality. A sub-analysis on individuals > 70 years old was conducted. Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used for assessing data quality and validity. Pooled data were obtained by using random-effects models.
resultsa total of 28 studies were included in this meta-analysis (26 observational studies and 2 randomized trials), reporting a total of 679,259 participants from different continents. Our results showed that high adherence to the MD reduces all-cause mortality risk by 23% (95% CI: 0.70-0.83), while it decreases the risk of cardiovascular mortality by 27% (95% CI: 0.64-0.84) and that of non-fatal cardiovascular events by 23% (95% CI: 0.55-1.01).
conclusionsMD is a promising dietary pattern for promoting health among older adults, as it is associated with reduced risks of all-cause and cardiovascular mortality, and non-fatal cardiovascular events. Adopting a Mediterranean Diet may contribute to better overall health and a lower likelihood of cardiovascular-related health issues in older individuals.
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