Evidence map›Paper›PMID 39600871›Full record

ArticleFrontiers in cellular and infection microbiology2024

The mammalian Ire1 inhibitor, 4µ8C, exhibits broad anti-

Manali M Kamath, Emily M Adams, Jorge D Lightfoot, Becca L Wells, Kevin K Fuller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Propranolol is efficacious againstAntimicrobial agents and chemotherapy · 2025
    Article
  3. Ire1 inhibitors attenuateFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Manali M KamathDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Emily M AdamsDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Jorge D LightfootDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Becca L WellsDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.
Kevin K FullerDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States.

Funding

Vascular-macrophage crosstalk in GBM immunosuppressionP20GM134973 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Sree Deepthi Muthukrishnan · 2020 to 2026
$17.6M
P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan, MICHAEL H ELLIOTT · 2011 to 2026
$10.5M
The unfolded protein response as a therapeutic target for fungal keratitisR01EY033866 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Kevin K. Fuller · 2022 to 2026
$1.9M
Vision Science Training ProgramT32EY023202 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI CALLEGAN, MICHELLE C · 2014 to 2025
$952k
NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY033866NEI NIH HHS T32 EY023202NIGMS NIH HHS P20 GM134973
6 · The paper itself

Abstract

Objective: The fungal unfolded protein response consists of a two-component relay in which the ER-bound sensor, IreA, splices and activates the mRNA of the transcription factor, HacA. Previously, we demonstrated that Methods: The antifungal activity of Ire1 inhibitors was tested against conidia of several Results: Among six Ire1 inhibitors screened, the endonuclease inhibitor 4μ8C displayed the strongest antifungal profile with an apparent fungicidal action. The compound both blocked conidial germination and hyphal metabolism of Conclusion: The

Indexed as

Antifungal AgentsAspergillosisAspergillus fumigatusDisease Models, AnimalKeratitisProtein Serine-Threonine KinasesAnimalsBiofilmsCorneaEndoribonucleasesEye Infections, FungalFemaleHumansMembrane ProteinsMiceMicrobial Sensitivity TestsAntifungal AgentsEndoribonucleasesErn2 protein, mouseMembrane ProteinsProtein Serine-Threonine Kinases4μ8CantifungalsAspergillus fumigatusfungal keratitisIRE1 inhibitors

Identifiers

PMID39600871
PMCPMC11588707

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.