ArticleFrontiers in endocrinology2024
Association between estimated glucose disposal rate and female infertility: a cross-sectional study.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Association between estimated glucose disposal rate and female infertility based on NHANES 2013 to 2020.Medicine · 2026Article
- Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients.PloS one · 2026Article
- Association between estimated glucose disposal rate and heart failure in patients with diabetes or prediabetes: a cross-sectional study.BMC public health · 2025Article
- Assessing the Impact of Estimated Glucose Disposal Rate (eGDR) on Cognitive Function in Older Adults: A NHANES-Based Machine Learning Study.CNS neuroscience & therapeutics · 2025Article
- Integrative regression modeling of insulin sensitivity, resistance, and beta-cell dysfunction in predicting female infertility: a cross-sectional NHANES study.Clinical and experimental medicine · 2025Article
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Authors and funding
4 authors.
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Abstract
Background: Insulin resistance (IR) can lead to infertility in women. The primary objective of this research was to examine how estimated glucose disposal rate (eGDR) correlates with infertility in women, assessing its validity as an indicator of IR. Methods: Data from the National Health and Nutrition Examination Survey spanning 2013 to 2018 were analyzed in this study. In order to investigate the correlation between eGDR and the prevalence of female infertility, this study used a combination of weighted multivariate regression analysis, restricted cubic spline (RCS) analysis, subgroup analyses, sensitive analysis, and receiver operating characteristic (ROC) curves. Results: This study enrolled 2541 women, with an average age of (32.52 ± 0.23) years. The overall infertility rate was 14.27%. A negative relationship was observed between eGDR levels and female infertility. Each increment of one unit in eGDR was linked to a 14% reduction in infertility incidence (OR = 0.86, 95% CI 0.80-0.94). RCS analysis revealed a nonlinear, inverse correlation between eGDR and female infertility. Subgroup analyses indicated that age influenced the association between eGDR and female infertility. The ROC curve suggested that eGDR was significantly better than HOMA-IR in predicting infertility [eGDR: 0.632 (95% CI: 0.603, 0.660) vs. HOMA-IR: 0.543 (95% CI: 0.514, 0.572)]. Conclusion: There was an observed association where lower eGDR levels were linked with higher rates of female infertility. These results emphasize the significance of implementing measures to manage IR to protect women's reproductive health.
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