Evidence map›Paper›PMID 39601104›Full record

ArticleJournal of medical virology2024

Development of Human Monoclonal Antibodies With Broad Reactivity for Rabies Postexposure Prophylaxis.

Meng Wu, Xinyu Peng, Weidi Xu, Hao Zhang, Lian Fang, Xueqin Liu, Faming Miao, Quan Liu, Shijiang Mi, Yuewen Xiao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medical virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Meng WuCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Xinyu PengDepartment of Hepatobiliary & Pancreas Surgery, The First Hospital of Jilin University, China.
Weidi XuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Hao ZhangR&D Department, Chongqing CAMAB BIOTECH Ltd., Chongqing, China.
Lian FangR&D Department, Chongqing CAMAB BIOTECH Ltd., Chongqing, China.
Xueqin LiuInstitute of Bioengineering, Chongqing Academy of Animal Sciences, Chongqing, China.
Faming MiaoChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Quan LiuDepartment of Infectious Diseases and Center for Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, The First Hospital of Jilin University, Changchun, China.
Shijiang MiChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Yuewen XiaoState Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonoses Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.
Xinglong YuCollege of Veterinary Medicine, Hunan Agricultural University, Changsha, China.
Changchun TuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.
Liangpeng GeInstitute of Bioengineering, Chongqing Academy of Animal Sciences, Chongqing, China.
Yan LiuChangchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, China.ORCID 0009-0006-6359-2615

Funding

This work was supported by the Chongqing Municipal Science and Technology Bureau, National Natural Science Foundation of China, and National Key Research and Development Program of China.
6 · The paper itself

Abstract

Rabies is an acute lethal disease causing by the neurotropic virus rabies virus (RABV). Rabies immune globulin (RIG) as an indispensable component of rabies postexposure prophylaxis (PEP) always faces with great challenges in terms of costs, stability and safety. Our objective is to develop a novel and potential fully human monoclonal antibodies (mAbs) cocktail for the improvement of rabies PEP. The neutralizing fully human mAbs were screened by using fully humanized antibody mice (CAMouse

Indexed as

Antibodies, MonoclonalAntibodies, NeutralizingAntibodies, ViralNeutralization TestsPost-Exposure ProphylaxisRabiesRabies virusAnimalsFemaleHumansMiceAntibodies, MonoclonalAntibodies, NeutralizingAntibodies, Viralhuman monoclonal antibodyIg G‐humanized transgenic miceneutralizing activitypostexposure prophylaxisrabies virus

Identifiers

PMID39601104
PMCPMC11600393

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.