Evidence map›Paper›PMID 39601819›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Toxicity study of silica nanoparticles following 94-day repeated oral administration in Sprague Dawley rats.

Xiqian Cao, Bin Xie, Mingxiao Xu, Jinfeng Li, Xiaoyu Dai, Yijun Tian, Jiqianzhu Zhang, Yun Chen, Lang Yan, Bin Zhang and 2 more

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiqian Cao *National Engineering Research Center for Marine Aquaculture, Marine Science and Technology College, Zhejiang Ocean University, Zhoushan, Zhejiang Province, 316004, China.
Bin Xie *School of Basic Medicine, Anhui Medical University, Anhui, 230032, China.
Mingxiao Xu *Department of Infection Diseases, First Affiliated Hospital of Navy Military Medical University, Shanghai, 200433, China.
Jinfeng LiDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Xiaoyu DaiDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Yijun TianDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Jiqianzhu ZhangDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Yun ChenDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Lang YanDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Bin ZhangDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Wenjing ShiDepartment of Naval Nutrition and Food Hygiene, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China.
Lijun RenDepartment of Health Toxicology, College of Naval Medicine, Naval Medical University, No. 800, Xiangyin Road, Yangpu District, Shanghai, 200433, China. lijunren@smmu.edu.cn.

Funding

National Key Research and Development Program of China 2022YFC2804105National Natural Science Foundation of China 22106122Naval Medical University Youth start-up fund 2023QN011Shanghai Municipal Health Commission-Outstanding Youth Foundation of Public Health GWVI-11.2-YQ35
6 · The paper itself

Abstract

This study was designed to investigate the toxic response of Sprague Dawley (SD) rats following oral administration of different doses of silica nanoparticles (SiNPs) for 94 consecutive days, as well as the recovery after 30 days of withdrawal. Rats were orally administered SiNPs at dosages of 0, 125, 250, and 500 mg/kg /day once a day for 94 continuous days. By the end of the study, there were no fatalities in any of the experimental animals that received SiNPs orally. Under the tested doses, no adverse effects related to SiNPs treatment were observed in a comprehensive assessment of several dimensions, including clinical signs, body weight changes, food consumption, hematological parameters, blood biochemical indices, urinalysis, organ weights and coefficients, and gross and histopathology. Based on the current study results, the No Observed Adverse Effect Level (NOAEL) for repeated oral administration of SiNPs in rats for 94 consecutive days was designated as 500 mg/kg/day.

Indexed as

NanoparticlesSilicon DioxideAdministration, OralAnimalsBody WeightDose-Response Relationship, DrugFemaleMaleNo-Observed-Adverse-Effect LevelOrgan SizeRatsRats, Sprague-DawleySilicon DioxideNOAELRatsSilica nanoparticlesToxicity

Identifiers

PMID39601819

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.