Evidence map›Paper›PMID 39601967›Full record

ArticleAngiogenesis2024

Retinal pigment epithelial cells reduce vascular leak and proliferation in retinal neovessels.

Simone Tzaridis, Edith Aguilar, Michael I Dorrell, Martin Friedlander, Kevin T Eade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angiogenesis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Simone TzaridisThe Lowy Medical Research Institute, La Jolla, CA, USA. stzaridis@scripps.edu.
Edith AguilarDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Michael I DorrellThe Lowy Medical Research Institute, La Jolla, CA, USA.
Martin FriedlanderThe Lowy Medical Research Institute, La Jolla, CA, USA.
Kevin T EadeThe Lowy Medical Research Institute, La Jolla, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In multiple neurodegenerative diseases, including age-related macular degeneration, retinitis pigmentosa, and macular telangiectasia type 2 (MacTel), retinal pigment epithelial (RPE)-cells proliferate and migrate into the neuroretina, forming intraretinal pigment plaques. Though these pigmentary changes are hallmarks of disease progression, it is unknown if their presence is protective or detrimental.Here, we first evaluated the impact of pigment plaques on vascular changes and disease progression in MacTel. In a retrospective, longitudinal study, we analyzed multimodal retinal images of patients with MacTel and showed that pigment plaques were associated with decreased vascular leakage and stabilized neovascular growth. We then modeled the underlying pathomechanisms of pigment plaque formation in aberrant neovascular growth using the very-low-density lipoprotein receptor mutant (Vldlr

Indexed as

Cell ProliferationReceptors, LDLRetinal Pigment EpitheliumAnimalsCell MovementEpithelial-Mesenchymal TransitionHumansMaleMiceMice, Inbred C57BLMice, KnockoutRetinal NeovascularizationRetinal TelangiectasisRetinal VesselsRetrospective StudiesReceptors, LDLVLDL receptorEpithelial-mesenchymal transitionMacular telangiectasia type 2NeovascularizationPigment migrationRetinal imagingVascular leakage

Identifiers

PMID39601967
PMCPMC11602807

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.