Evidence map›Paper›PMID 39602257›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Genetic evidence against involvement of TRPC proteins in SOCE, ROCE, and CRAC channel function.

Sebastian Susperreguy, Megumi Yamashita, Chan-Il Choi, Yanhong Liao, Lauranell H Burch, Terry L Blankenship, Erika Hayes, Thomas Sliwa, Yingpei Zhang, Dagoberto Grenet and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sebastian Susperreguy *Institute of Biomedical Research, School of Biomedical Sciences, Catholic University of Argentina, Buenos Aires C1107AFF, Argentina.
Megumi Yamashita *Department of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.
Chan-Il Choi *Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Yanhong Liao *Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Lauranell H BurchMolecular Genetics Core Laboratory and Laboratory of Molecular Genetics, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
Terry L BlankenshipComparative Medicine Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
Erika HayesComparative Medicine Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
Thomas SliwaComparative Medicine Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709.
Yingpei ZhangLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Dagoberto GrenetLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Mitzie WalkerLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Nicholas W PlummerLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Joel AbramowitzLaboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
Jean Pierre KinetLaboratory of Allergy and Immunology, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115.
Karina FormosoInstitute of Biomedical Research, School of Biomedical Sciences, Catholic University of Argentina, Buenos Aires C1107AFF, Argentina.
Brandon E JohnsonCenter for Biomedical Research, The Queen's Medical Center, Honolulu, HI 96813.
Andrea FleigCenter for Biomedical Research, The Queen's Medical Center, Honolulu, HI 96813.
Lori HazlehurstDepartment of Pharmaceutical Sciences, West Virginia University, Morgantown, WV 26506.
Reinhold PennerCenter for Biomedical Research, The Queen's Medical Center, Honolulu, HI 96813.
Marc FreichelInstitute of Experimental and Clinical Pharmacology and Toxicology, University of the Saarland, Homburg D66421, Germany.ORCID 0000-0003-1387-2636
Veit FlockerziInstitute of Experimental and Clinical Pharmacology and Toxicology, University of the Saarland, Homburg D66421, Germany.
Murali PrakriyaDepartment of Pharmacology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.ORCID 0000-0003-0781-4480
Lutz BirnbaumerInstitute of Biomedical Research, School of Biomedical Sciences, Catholic University of Argentina, Buenos Aires C1107AFF, Argentina.ORCID 0000-0002-0775-8661

Funding

Store-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4M
The Physiology of Store-Operated Channels in the Nervous SystemR35NS132349 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Murali Prakriya · 2023 to 2026
$3.7M
Modulation of pain mechanisms by cannabis-derived phytochemicals.R01AT011162 · NCCIH · QUEEN'S MEDICAL CENTER · PI MACKIE, KENNETH, PENNER, REINHOLD · 2021 to 2025
$3.2M
Transmembrane Signaling Mechanisms Involving TRP ChannelsZ01ES101684 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI BIRNBAUMER, LUTZ · 2003 to 2008
$2.1M
Targeting CD44-mediated calcium signaling for the treatment of relapsed myelomaR01CA195727 · NCI · WEST VIRGINIA UNIVERSITY · PI HAZLEHURST, LORI A · 2015 to 2019
$1.7M
HHS | National Institutes of Health (NIH) R01-CA195727HHS | National Institutes of Health (NIH) R01-NS057499HHS | National Institutes of Health (NIH) R35-132349HHS | NIH | NIDA | Intramural Research Program (IRP) Project Z01-ES101684Intramural NIH HHS Z01 ES101684NCCIH NIH HHS R01 AT011162NCI NIH HHS R01 CA195727NINDS NIH HHS R01 NS057499NINDS NIH HHS R35 NS132349
6 · The paper itself

Abstract

Using genetically engineered mice and cell lines derived from genetically engineered mice we show that depletion of ER delimited Ca

Indexed as

CalciumTRPC Cation ChannelsAnimalsCalcium ChannelsCalcium Release Activated Calcium ChannelsCalcium SignalingMiceMice, KnockoutORAI1 ProteinCalciumCalcium ChannelsCalcium Release Activated Calcium ChannelsORAI1 ProteinOrai1 protein, mouseTRPC Cation ChannelsOraiROCESOCETRPC

Identifiers

PMID39602257
PMCPMC11626178

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.