Observational studyClinical endocrinology2025
Defining Clinical Characteristics of Individuals With and Without Post-Bariatric Hypoglycemia After Gastric Bypass.
Observational study in Clinical endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Plasma GDF15 increases during hyperinsulinemic hypoglycemia in humans with post-bariatric hypoglycemia and after insulin exposure in mice.Cell reports. Medicine · 2026Observational
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Authors and funding
8 authors.
Funding
Abstract
contextPost-bariatric hypoglycemia (PBH) is a complication of bariatric surgery including Roux-en-Y gastric bypass (RYGB). It remains unclear why only some individuals develop PBH.
objectiveTo identify clinical characteristics distinguishing post-RYGB individuals with PBH, versus without symptomatic hypoglycemia (RYGB non-hypo). DESIGN AND
settingCross-sectional observational study in academic referral centre. Adults 18-70, without current diabetes, were recruited into three groups: (1) PBH (n = 39); (2) RYGB non-hypo (n = 25); and (3) individuals without history of upper gastrointestinal surgery (n = 17). Outcome measures included between-group differences in medical history and medication use, and survey-based scores for hypoglycemia, dumping syndrome, and autonomic symptoms.
resultsPBH participants were 92% female, age 53.4 ± 11.9 y, BMI 31.2 ± 5.6 kg/m
conclusionHigh rates of IBS, dumping symptoms, and orthostatic hypotension suggest disordered autonomic regulation as a potential contributor to PBH. Self-reported preoperative symptoms and family history of hypoglycemia suggest possible preoperative differences in glucose metabolism in PBH.
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