Evidence map›Paper›PMID 39604443›Full record

ArticleNature communications2024

Rab8a restores diverse innate functions in CD11c

Sudhakar Singh, Azeez Tehseen, Surbhi Dahiya, Yuviana J Singh, Roman Sarkar, Sharvan Sehrawat

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sudhakar SinghDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India.
Azeez TehseenDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India.ORCID 0000-0002-6179-513X
Surbhi DahiyaDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India.
Yuviana J SinghDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India.
Roman SarkarDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India.
Sharvan SehrawatDepartment of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar Knowledge City PO Manauli, Mohali, 140306, Punjab, India. sharvan@iisermohali.ac.in.ORCID 0000-0001-5745-6955

Funding

DST | Science and Engineering Research Board (SERB) DST-IPA/2020/00091DST | Science and Engineering Research Board (SERB) DST-IPA/2021/00136
6 · The paper itself

Abstract

Age-related alterations of the immune system compromise the host's ability to respond to pathogens, but how immune aging is regulated is still poorly understood. Here, we identify via transcriptomic analysis of splenic DCs and bone marrow derived dendritic cells (BMDC) of young and aged mice, the small GTPase Rab8a as a regulator of dendritic cell (DC) functions in mice. CD11c

Indexed as

AgingCD11b AntigenCD8-Positive T-LymphocytesDendritic CellsMice, Inbred C57BLrab GTP-Binding ProteinsAnimalsAntigen PresentationCD11c AntigenFemaleHistocompatibility Antigens Class IImmunity, InnateInterferon Type IMicerab11 GTP-Binding ProteinsSpleenCD11b AntigenCD11c AntigenHistocompatibility Antigens Class IInterferon Type IItgam protein, mouserab11 GTP-Binding ProteinsRab8a protein, mouserab GTP-Binding Proteins

Identifiers

PMID39604443
PMCPMC11603169

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.