ArticleEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2025
Higher charlson comorbidity index score correlates with higher rate of pseudoarthrosis following short-segment lumbar fusion surgery.
Article in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Absence of bone marrow edema on early postoperative MRI predicts fusion outcome after single-level lumbar interbody fusion.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Role of paraspinal muscle fatty infiltration in predicting adjacent segment disease after lumbar spinal fusion: a systematic review and meta-analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- The impact of metabolic syndrome on one-year patient-reported outcomes after lumbar fusion surgery.North American Spine Society journal · 2025Article
- Spinoplastic Surgery: A Review of Techniques, Indications, and Optimal Patient Selection.Brain sciences · 2025Review
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Authors and funding
14 authors.
Funding
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Abstract
purposeIn the present study, we aimed to analyze whether the Charlson Comorbidity Index (CCI) score was predictive for pseudoarthrosis in patients who underwent with short-segment lumbar decompression and fusion for degenerative lumbar spine disorders (DSD).
methodsConsecutive patients who underwent short-segment lumbar decompression and fusion for DSD between 2013 and 2023 in a tertiary spine clinic were included into the study. Patients' charts were reviewed for patients' comorbidities, smoking status, and the CCI score was calculated accordingly. Subcutaneous fat index (SFI) was used for the anthropometric evaluation of the participants.
resultsComorbidities/smoking had no significant effect on the pseudoarthrosis rate, when analyzed separately. However, subjects with pseudoarthrosis at their final follow-up visits had significantly higher CCI scores at the pre-operative era compared to the subjects without pseudoarthrosis (p = 0.022). Besides, in patients with pseudoarthrosis and those without pseudoarthrosis 48.1% and 75.3% were overweight according to SFI, respectively (p = 0.003). Multivariable regression analysis depicted ORs of 1.256 (p = 0.018) for the CCI score and 0.269 (p = 0.003) for overweight. The ROC analysis revealed a cut-off value of 2.5 points for the CCI score.
conclusionA combined effect of comorbidities might yield higher pseudoarthrosis rates following short-segment decompression and fusion for DSD. Each one-point increment in CCI score and SFI score yielded a 26% increment and a 73% decrement in risk for pseudoarthrosis in those subjects. A cut-off value of 2.5 points for the CCI score could distinguish the subjects who might have pseudoarthrosis following short-segment surgery for DSD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.