Evidence map›Paper›PMID 39604670›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2026

Circulating RBP4 and FABP4 concentrations in patients with chronic schizophrenia are associated with increased epicardial adipose tissue volume and metabolic syndrome.

Thung-Lip Lee, Chin-Feng Hsuan, Nan-Han Lu, I-Ting Tsai, Chia-Chang Hsu, Chao-Ping Wang, Yung-Chuan Lu, Tsung-Ming Hu, Fu-Mei Chung, Yau-Jiunn Lee and 1 more

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Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Thung-Lip LeeDivision of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Chin-Feng HsuanDivision of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Nan-Han LuSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan.
I-Ting TsaiSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, 82445, Taiwan.
Chia-Chang HsuDivision of Gastroenterology and Hepatology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Chao-Ping WangDivision of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Yung-Chuan LuDivision of Endocrinology and Metabolism, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Tsung-Ming HuDepartment of Psychiatry, Taipei Veterans General Hospital, Yuli Branch, Hualien, 98142, Taiwan.
Fu-Mei ChungDivision of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, 82445, Taiwan.
Yau-Jiunn LeeLee's Endocrinologic Clinic, Pingtung, 90000, Taiwan.
Wei-Hua TangDivision of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Yuli Branch, No. 91, Xinxing St., Yuli Township, Hualien, 981002, Taiwan. africapaul12@yahoo.com.ORCID http://orcid.org/0000-0002-3338-9505

Funding

E-Da hospital EDAHP103052E-Da hospital EDAHP113019Taipei Veterans General Hospital, Yuli Branch VHYL-112-003
6 · The paper itself

Abstract

Schizophrenia has been linked to an elevated cardiovascular risk profile and premature onset of cardiovascular disease. Quantifying epicardial adipose tissue (EAT) volume provides insight into its correlation with coronary artery disease (CAD) severity and associated risk factors. Previous research indicates higher pericardial adipose tissue in individuals with schizophrenia compared to non-schizophrenic counterparts. RBP4, FABP3, and FABP4 have been implicated in CAD pathogenesis. In this study, we examined the potential increase in EAT volume in individuals with chronic schizophrenia and aimed to elucidate the relationship between circulating levels of RBP4, FABP3, and FABP4 with EAT volume and coronary artery calcium score within this cohort. We recruited 186 consecutive patients with chronic schizophrenia and utilized enzyme-linked immunosorbent assay to assess plasma concentrations of RBP4, FABP3, and FABP4. Cardiac multislice computed tomography measured EAT volume and coronary artery calcium scores. Significantly higher EAT volume in patients with chronic schizophrenia compared to controls. RBP4 associated positively with metabolic factors and EAT volumes, while FABP3 associated positively with creatinine and coronary atherosclerosis markers. FABP4 showed positive associations with metabolic factors, hypertension, and EAT volumes, but negative associations with HDL-C and eGFR. Logistic regression identified RBP4 and FABP4 as independent factors associated with increased EAT volumes, even after adjusting for known biomarkers. Both RBP4 and FABP4 were significantly associated with metabolic syndrome components and EAT volume. This study elucidates the association between chronic schizophrenia and augmented EAT volume, suggesting plausible correlations with CAD-related health complications through RBP4 and FABP4 pathways.

Indexed as

Adipose TissueCoronary Artery DiseaseFatty Acid-Binding ProteinsMetabolic SyndromePericardiumRetinol-Binding Proteins, PlasmaSchizophreniaAdultAgedChronic DiseaseEpicardial Adipose TissueFatty Acid Binding Protein 3FemaleHumansMaleMiddle AgedFABP3 protein, humanFABP4 protein, humanFatty Acid Binding Protein 3Fatty Acid-Binding ProteinsRBP4 protein, humanRetinol-Binding Proteins, PlasmaChronic schizophreniaCoronary artery calcium scoreCoronary artery diseaseEpicardial adipose tissue volumeFatty acid-binding proteinRetinol-binding protein

Identifiers

PMID39604670

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.