ArticlebioRxiv : the preprint server for biology2024
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Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Authors and funding
30 authors.
Christiano R R AlvesCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-2646-9689
Sabyasachi DasCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-6243-2058
Vijai KrishnanCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-5979-1255
Leillani L HaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-4478-660X
Lauren R FoxCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0003-4828-8365
Hannah E StutzmanCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-0500-437X
Claire E ShamberCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0003-2049-2057
Pazhanichamy KalailingamCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7689-275X
Siobhan McCarthyCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Christian L Lino CardenasDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Claire E FongCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Takahiko ImaiNeurovascular Research Unit, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Sunayana MitraCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
Shuqi YunCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0009-0006-2228-6515
Rachael K WoodDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Friederike M C BenningDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-1002-4204
Joseph LawtonDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Nahye KimCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-4539-6382
Rachel A SilversteinCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-5724-2252
Joana Ferreira da SilvaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7090-1264
Demitri de la CruzDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rashmi RichaDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2800-0419
Rajeev MalhotraDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-0120-4630
David Y ChungDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-7149-5851
Luke H ChaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-4849-4148
Shengdar Q TsaiDepartment of Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0001-9161-3993
Casey A MaguireDepartment of Neurology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-8681-5179
Mark E LindsayDivision of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-6724-7938
Benjamin P KleinstiverCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5469-0655
Patricia L MusolinoCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0001-8724-5649
Funding
PROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Matthias Nahrendorf · 2019 to 2026
$19.5MModeling and Therapeutic Approaches for Genetic VasculopathiesR01NS125353 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI MARK E LINDSAY, Patricia L Musolino · 2022 to 2026
$3.5MProbing structural and biophysical mechanisms of mitochondrial membrane ultrastructureR35GM142553 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Luke H. Chao · 2021 to 2026
$2.6MThe Role of Arylsulfatase in Vascular CalcificationR01HL162928 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI PAUL STEFAN DE VRIES, Rajeev Malhotra · 2023 to 2026
$2.6MScalable Development of Custom Genome Editing TechnologiesDP2CA281401 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI KLEINSTIVER, BENJAMIN PETER · 2022 to 2025
$2.5MEnhanced gene delivery for CNS and sensory disordersR01DC017117 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI MAGUIRE, CASEY A · 2019 to 2023
$1.8MSensitive, unbiased, high-throughput, cellular GUIDE-seq-2 genome-wide activity assay for therapeutic genome editing INDsU01AI176470 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TSAI, SHENGDAR · 2023 to 2025
$1.4MUltra-sensitive, unbiased, high-throughput, biochemical CHANGE-seq genome-wide activity and gRNA sequencing assays for therapeutic genome editing INDsU01AI176471 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TSAI, SHENGDAR · 2023 to 2025
$1.4MDeterminants of Functional Brain Connectivity After Subarachnoid HemorrhageK08NS112601 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CHUNG, DAVID YOUNG · 2019 to 2023
$1.0MNovel molecular mechanisms of vascular smooth muscle cell-mediated large and small artery calcificationK01HL164687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Christian Lacks Lino Cardenas · 2022 to 2026
$808kDevelopment of in Vivo Base Editing as a Genetic Treatment for Spinal Muscular AtrophyK01NS134784 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Christiano Alves · 2024 to 2026
$726kNCI NIH HHS DP2 CA281401NHLBI NIH HHS K01 HL164687NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R01 HL162928NIAID NIH HHS U01 AI176470NIAID NIH HHS U01 AI176471NIDCD NIH HHS R01 DC017117NIGMS NIH HHS R35 GM142553NINDS NIH HHS K01 NS134784NINDS NIH HHS K08 NS112601NINDS NIH HHS R01 NS125353
Abstract
Genetic vascular disorders are prevalent diseases that have diverse etiologies and few treatment options. Pathogenic missense mutations in the alpha actin isotype 2 gene (
Indexed as
ACTA2aortic aneurysmbase editingbystander editingCRISPR-Casgenome editingMDMSmoyamoya diseaseMSMDSpediatric diseasevasculopathies
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.