Evidence map›Paper›PMID 39605393›Full record

ArticlebioRxiv : the preprint server for biology2024

Lewy-MSA hybrid fold drives distinct neuronal α-synuclein pathology.

Masahiro Enomoto, Ivan Martinez-Valbuena, Shelley L Forrest, Xiaoxiao Xu, Renato P Munhoz, Jun Li, Ekaterina Rogaeva, Anthony E Lang, Gabor G Kovacs

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Masahiro EnomotoPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, M5G 1L7, Canada.ORCID 0000-0002-9411-2999
Ivan Martinez-ValbuenaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.ORCID 0000-0001-6463-6321
Shelley L ForrestTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.ORCID 0000-0001-7863-5389
Xiaoxiao XuDepartment of Medical Biophysics, University of Toronto, Toronto, Canada.
Renato P MunhozEdmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, M5T 2S8, Toronto, Ontario, Canada.ORCID 0000-0002-4783-4067
Jun LiTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.ORCID 0000-0002-2852-0329
Anthony E LangTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.ORCID 0000-0003-1229-3667
Gabor G KovacsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.ORCID 0000-0003-3841-5511

Funding

Identification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation.R01AG080001 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BERNARDINO Francesco GHETTI, RUBEN VIDAL · 2023 to 2026
$2.7M
NIA NIH HHS R01 AG080001
6 · The paper itself

Abstract

The ordered assembly of α-synuclein protein into filaments encoded by SNCA characterizes neurodegenerative diseases called synucleinopathies. Lewy body disease (LBD) shows predominantly neuronal α-synuclein pathology and multiple system atrophy (MSA) predominantly oligodendrocytic α-synuclein pathology affecting subcortical brain structures. Based on cryo-electron microscopy, it was reported that structures of α-synuclein filaments from LBD differ from MSA and juvenile onset synucleinopathy (JOS) caused by a 21-nucleotide duplication in the second exon of one allele of

Identifiers

PMID39605393
PMCPMC11601602

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.