ArticlebioRxiv : the preprint server for biology2025
A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins.
Daniel J Kelpsch, Liyun Zhang, James H Thierer, Kobe Koren, Urmi Kumar, Yuki Lin, Monica R Hensley, Mira Sohn, Jun O Liu, Thomas Lectka and 2 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
12 authors.
Liyun ZhangDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.
James H ThiererDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.
Urmi KumarDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Yuki LinDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Monica R HensleyDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Mira SohnDepartment of Biology, Johns Hopkins University, Baltimore, United States.
Jun O LiuDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.
Thomas LectkaDepartment of Chemistry, Johns Hopkins University, Baltimore, United States.
Jeff S MummDepartment of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, United States.ORCID 0000-0002-2575-287X Funding
Wilmer Core Grant for Vision ResearchP30EY001765 · NEI · JOHNS HOPKINS UNIVERSITY · PI JEFFREY MUMM · 1985 to 2026
$22.1MCellular and Molecular BiologyT32GM141804 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI John Kim · 2021 to 2026
$5.1MIn vivo HTS assay for novel modulators of Apolipoprotien BR01DK116079 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI FARBER, STEVEN A · 2018 to 2022
$3.2MHigh-throughput Phenotypic Screening (HPS) Platform for Large-scale Drug Discovery in Whole-organism and Human Organoid-based Disease ModelsS10OD026909 · OD · JOHNS HOPKINS UNIVERSITY · PI MUMM, JEFFREY · 2020 to 2020
$1.9MDefining the role of PLA2G12B on apoB-containing lipoprotein assembly, plasma levels, metabolism and cardiovascular disease riskR01DK138195 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI STEVEN A FARBER, M Mahmood Hussain · 2025 to 2026
$1.2MA whole-animal small molecule screen to identify and characterize modifiers of Apolipoprotein BF32DK126297 · NIDDK · CARNEGIE INSTITUTION OF WASHINGTON, D.C. · PI KELPSCH, DANIEL · 2020 to 2022
$201kNEI NIH HHS P30 EY001765NIDDK NIH HHS F32 DK126297NIDDK NIH HHS R01 DK116079NIDDK NIH HHS R01 DK138195NIGMS NIH HHS T32 GM141804NIH HHS S10 OD026909
6 · The paper itselfAbstract
Lipoproteins are essential for lipid transport in all bilaterians. A single Apolipoprotein B (ApoB) molecule is the inseparable structural scaffold of each ApoB-containing lipoprotein (B-lps), which are responsible for transporting lipids to peripheral tissues. The cellular mechanisms that regulate ApoB and B-lp production, secretion, transport, and degradation remain to be fully defined. In humans, elevated levels of vascular B-lps play a causative role in cardiovascular disease. Previously, we have detailed that human B-lp biology is remarkably conserved in the zebrafish using an
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PMID39605440
PMCPMC11601432
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