Evidence map›Paper›PMID 39605606›Full record

ArticlebioRxiv : the preprint server for biology2025

Heterogeneous endocrine cell composition defines human islet functional phenotypes.

Carmella Evans-Molina, Yasminye D Pettway, Diane C Saunders, Seth A Sharp, Thomas Sr Bate, Han Sun, Heather Durai, Shaojun Mei, Anastasia Coldren, Corey Davis and 20 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors.

Carmella Evans-MolinaDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Yasminye D PettwayDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Diane C SaundersDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Seth A SharpDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.
Thomas Sr BateDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Han SunDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.
Heather DuraiDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Shaojun MeiDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Anastasia ColdrenDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Corey DavisDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Conrad V ReihsmannDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Alexander L HopkirkDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jay TaylorDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Amber BradleyDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Radhika AramandlaDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Greg PoffenbergerDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Adel EskarosDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Regina JenkinsDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Danni ShiDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ke XuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Hakmook KangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Varsha RajeshDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.
Swaraj ThamanDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.
Fan FengDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Jean-Philippe CartaillerVanderbilt Center for Stem Cell Biology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-0312-2391
Alvin C PowersDepartment of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Kristin AbrahamDivision of Diabetes, Endocrinology, & Metabolic Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Anna L GloynDepartment of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-1205-1844
Joyce C NilandDepartment of Diabetes and Cancer Discovery Science, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA.
Marcela BrissovaDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.ORCID 0000-0002-4999-3280

Funding

Limited Competition: Continued Follow-up of Subjects and Initiation of a Second Case-control Cohort in The Environmental Determinants of Diabetes in The Young Study (TEDDY)U01DK128847 · NIDDK · UNIVERSITY OF SOUTH FLORIDA · PI JEFFREY P KRISCHER · 2021 to 2026
$79.2M
Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
TRANSGENIC MOUSE/ ES CELL SHARES RESOURCESP60DK020593 · NIDDK · VANDERBILT UNIVERSITY · PI ELASY, TOM A · 1986 to 2011
$28.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
The Human Islet Distribution Coordinating Center (UC4)UC4DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI EVANS-MOLINA, CARMELLA, NILAND, JOYCE CAROL · 2012 to 2017
$25.6M
The Human Pancreas Analysis Program for Type 2 DiabetesU01DK123594 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI Robert Babak Faryabi, KLAUS H KAESTNER · 2019 to 2026
$25.0M
NATIONAL ISLET CELL CONSORTIUM COORDINATING CENTERU42RR017673 · NCRR · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI NILAND, JOYCE CAROL · 2002 to 2008
$18.8M
Penn integrated Human Pancreas procurement and Analysis ProgramUC4DK112217 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BETTS, MICHAEL R, FELDMAN, MICHAEL D · 2016 to 2020
$17.8M
Integrated Islet Distribution Program (U24) - 2021U24DK098085 · NIDDK · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Carmella Evans-Molina, Joyce Carol Niland · 2021 to 2026
$17.8M
Translation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Tamara S Hannon · 2015 to 2026
$17.4M
PanKbase: a community hub for integrated pancreas knowledgeU24DK138515 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Marcela Brissova, Jean-Philippe Cartailler · 2024 to 2026
$11.3M
An interactive resource to generate and provide integrated knowledge of the human pancreasU24DK138512 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Noel P Burtt, Jason Flannick · 2024 to 2026
$9.6M
BLRD VA I01 BX000666BLRD VA I01 BX001733NCRR NIH HHS U42 RR017673NIDDK NIH HHS F30 DK134041NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK097512NIDDK NIH HHS P60 DK020593NIDDK NIH HHS R01 DK127236NIDDK NIH HHS R01 DK129469NIDDK NIH HHS U01 DK123594NIDDK NIH HHS U01 DK123716NIDDK NIH HHS U01 DK128847NIDDK NIH HHS U24 DK098085NIDDK NIH HHS U24 DK138512NIDDK NIH HHS U24 DK138515NIDDK NIH HHS UC4 DK098085NIDDK NIH HHS UC4 DK112217NIDDK NIH HHS UC4 DK112232NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

Phenotyping and genotyping initiatives within the Integrated Islet Distribution Program (IIDP), the largest source of human islets for research in the U.S., provide standardized assessment of islet preparations distributed to researchers, enabling the integration of multiple data types. Data from islets of the first 299 organ donors without diabetes, analyzed using this pipeline, highlights substantial heterogeneity in islet cell composition associated with hormone secretory traits, sex, reported race and ethnicity, genetically predicted ancestry, and genetic risk for type 2 diabetes (T2D). While α and β cell composition influenced insulin and glucagon secretory traits, the abundance of δ cells showed the strongest association with insulin secretion and was also associated with the genetic risk score (GRS) for T2D. These findings have important implications for understanding mechanisms underlying diabetes heterogeneity and islet dysfunction and may provide insight into strategies for personalized medicine and β cell replacement therapy.

Indexed as

alpha cellsbeta cellsdelta cellsglucagon secretionHuman isletsinsulin secretionT1DT2D genetic risk score

Identifiers

PMID39605606
PMCPMC11601672

What Socratic holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.