Evidence map›Paper›PMID 39606329›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity.

Marlena Fejzo, Xinran Wang, Julia Zöllner, Natàlia Pujol-Gualdo, Triin Laisk, Estonian Biobank Research Team, Sarah Finer, David A van Heel, Genes & Health Research Team, Ben Brumpton and 21 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Marlena FejzoDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.
Xinran WangDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.
Julia ZöllnerUCL EGA Institute for Women's Health, University College London, London, United Kingdom.
Natàlia Pujol-GualdoEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Triin LaiskEstonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Estonian Biobank Research Team
Sarah FinerWolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
David A van HeelWolfson Institute of Population Health, Queen Mary University of London, London, United Kingdom.
Genes & Health Research Team
Ben BrumptonHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Laxmi BhattaHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim 7030, Norway.
Elizabeth A JasperVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Digna R Velez EdwardsVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Jacklyn N HellwegeVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Todd EdwardsVanderbilt University Medical Center, Nashville, TN. 37221. My affiliation specifically is Department of Obstetrics and Gynecology, Division of Quantitative and Clinical Sciences.
Gail P JarvikDepartments of Medicine (Medical Genetics) and Genome Sciences, University of Washington Medical Center, Seattle, WA, USA.
Yuan LuoDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago IL 60611.
Atlas KhanDivision of Nephrology, Dept of Medicine, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY.
Kimber MacGibbonHyperemesis Education and Research Foundation, Clackamas, OR 97089 USA.
Yuan GaoKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031.
Gaoxiang GeKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai 200031.
Inna AverbukhDepartment of Pathology, Stanford University, Stanford, CA, United States.
Erin SoonDepartment of Pathology, Stanford University, Stanford, CA, United States.
Michael AngeloDepartment of Pathology, Stanford University, Stanford, CA, United States.
Per MagnusNorwegian Institute of Public Health, Oslo, Norway.
Stefan JohanssonMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Pål R NjølstadMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Marc VaudelMohn Center for Diabetes Precision Medicine, Department of Clinical Science, University of Bergen, Bergen, Norway.
Chang ShuDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.
Nicholas MancusoDepartment of Population and Public Health Science, Center for Genetic Epidemiology, University of Southern California Keck School of Medicine, Los Angeles, CA, 90033 United States.

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
The eMERGE Risk Assessment Network - Coordinating CenterU01HG011166 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Niall John Lennon, Joseph F. Peterson · 2020 to 2026
$16.8M
Genomic Basis of Susceptibility to COVID-19 Infection and its ComplicationsU01HG006379 · NHGRI · MAYO CLINIC ROCHESTER · PI Richard R. Sharp · 2011 to 2026
$16.5M
Finding Genomic Profiles of COVID-19 Phenotypes from the EHRU01HG008685 · NHGRI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIZABETH W KARLSON, Matthew S Lebo · 2015 to 2026
$13.6M
Variation, Function, and Disease Supplement ProgramU01HG008657 · NHGRI · UNIVERSITY OF WASHINGTON · PI David Russell Crosslin, Gail Pairitz Jarvik · 2015 to 2026
$13.4M
OMOP information model for eMERGE phenotypingU01HG008680 · NHGRI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wendy K Chung, GEORGE M HRIPCSAK · 2015 to 2026
$13.3M
DNA Sequencing Support for the eMERGE NetworkU01HG008664 · NHGRI · BAYLOR COLLEGE OF MEDICINE · PI GIBBS, RICHARD A · 2015 to 2019
$10.9M
Pacific Center for Genome ResearchU54HG013243 · NHGRI · UNIVERSITY OF HAWAII AT MANOA · PI Alexandra Margaret Lynn Binder, Youping Deng · 2023 to 2026
$10.8M
Genomic risk in clinic care to promote health equity in New York City patientsU01HG011176 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI NOURA SERENE ABUL-HUSN, Eimear Elizabeth Kenny · 2020 to 2026
$10.4M
Utilizing Polygenic Risk to Understand and Improve Outcomes: A Model For Overturning Health Disparities Through Minority-Enriched Genomics HealthcareU01HG011175 · NHGRI · CHILDREN'S HOSP OF PHILADELPHIA · PI Hakon Hakonarson · 2020 to 2026
$10.3M
Integrating Genomic Risk Assessment for Disease Management in a Clinical PopulationU01HG011167 · NHGRI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JAMES J CIMINO, NITA A LIMDI · 2020 to 2026
$9.3M
NCI NIH HHS R01 CA258808NHGRI NIH HHS R01 HG012133NHGRI NIH HHS U01 HG006379NHGRI NIH HHS U01 HG008657NHGRI NIH HHS U01 HG008664NHGRI NIH HHS U01 HG008666NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01 HG008673NHGRI NIH HHS U01 HG008676NHGRI NIH HHS U01 HG008679NHGRI NIH HHS U01 HG008680NHGRI NIH HHS U01 HG008684NHGRI NIH HHS U01 HG008685NHGRI NIH HHS U01 HG008701NHGRI NIH HHS U01 HG011166NHGRI NIH HHS U01 HG011167NHGRI NIH HHS U01 HG011169NHGRI NIH HHS U01 HG011172NHGRI NIH HHS U01 HG011175NHGRI NIH HHS U01 HG011176NHGRI NIH HHS U01 HG011181NHGRI NIH HHS U54 HG013243NIAMS NIH HHS K12 AR084232NIEHS NIH HHS N01 ES075558NIGMS NIH HHS R01 GM140287NIMHD NIH HHS U54 MD007593NINDS NIH HHS U01 NS047537Wellcome Trust
6 · The paper itself

Abstract

While most pregnancies are affected by nausea and vomiting, hyperemesis gravidarum (HG) is at the severe end of the clinical spectrum and is associated with dehydration, undernutrition, and adverse maternal, fetal, and child outcomes. Herein we performed a multi-ancestry genome-wide association study (GWAS) of severe nausea and vomiting of pregnancy of 10,974 cases and 461,461 controls across European, Asian, African, and Latino ancestries. We identified ten significantly associated loci, of which six were novel (

Identifiers

PMID39606329
PMCPMC11601681

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.