Evidence mapPaperPMID 39606362Full record

ArticlemedRxiv : the preprint server for health sciences2024

Denoising diffusion model for increased performance of detecting structural heart disease.

Christopher D Streiffer, Michael G Levin, Walter R Witschey, Emeka C Anyanwu

Abstract readPreprint
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Christopher D StreifferDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104.ORCID 0000-0003-0684-4354
Michael G LevinDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104.ORCID 0000-0002-9937-9932
Walter R WitscheyDvision of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104.ORCID 0000-0003-1669-2120
Emeka C AnyanwuDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104.

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$1.1M
LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIAR01HL171709 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$751k
Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarctionR01HL169378 · UNIVERSITY OF PENNSYLVANIA · 2025 to 2025
$745k
Unraveling the Genetic Basis and Cardiovascular Impact of Lipoprotein(a) in Diverse PopulationsIK2BX006551 · PHILADELPHIA VA MEDICAL CENTER · 2025 to 2025
BLRD VA IK2 BX006551NHLBI NIH HHS R01 HL169378NHLBI NIH HHS R01 HL171709NIBIB NIH HHS P41 EB029460
6 · The paper itself

Abstract

Recent advancements in generative artificial intelligence have shown promise in producing realistic images from complex data distributions. We developed a denoising diffusion probabilistic model trained on the CheXchoNet dataset, encoding the joint distribution of demographic data and echocardiogram measurements. We generated a synthetic dataset skewed towards younger patients with a higher prevalence of structural left ventricle disease. A diagnostic deep learning model trained on the synthetic dataset performed comparably to one trained on real data producing an AUROC=0.75(95%CI 0.72-0.77), with similar performance on an internal dataset. Combining real data with positive samples from the synthetic data improved diagnostic accuracy producing an AUROC=0.80(95%CI 0.78-0.82). Subgroup analysis showed the largest performance improvement across younger patients. These results suggest diffusion models can increase diagnostic accuracy and fine-tune models for specific populations.

Indexed as

Diffusion ModelGenerative AIMedical ImagingStructural Heart DiseaseSynthetic Data

Identifiers

PMID39606362
PMCPMC11601717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.