ArticleCancer medicine2024
Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study.
Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Body Roundness Index and Incident Colorectal Cancer Risk: A Nationwide Population-Based Cohort Study.Cancers · 2026Article
- Trajectories of adiposity indices and the risk of cardiovascular disease and mortality: a prospective cohort study.Journal of translational medicine · 2026Article
- Evaluating the predictive power of the body roundness index (BRI) versus traditional obesity measures for female infertility: a hybrid approach using regression models and machine learning algorithms on cross-sectional data.Journal of health, population, and nutrition · 2025Article
- Body roundness index as a novel anthropometric predictor of sarcopenia in patients with cancer: a bicontinental cohort study across Chinese and American populations.Lipids in health and disease · 2025Article
- Central Adiposity Assessed with Body Roundness Index and Mortality: The Seguimiento Universidad de Navarra Prospective Cohort.Geriatrics (Basel, Switzerland) · 2025Article
- Baseline and longitudinal changes of body roundness index and incident type 2 diabetes: evidence from the UK Biobank cohort.BMJ open diabetes research & care · 2025Article
- The relationship between body roundness index (BRI) and suicidal ideation: evidence from NHANES 2013-2018.BMC psychiatry · 2025Article
- Independent role of two novel abdominal fat indicators in chronic diarrhoea.Frontiers in medicine · 2025Article
- The association between body roundness index and sarcopenia in older adults: a population-based study.Frontiers in public health · 2025Article
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Authors and funding
13 authors.
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Abstract
backgroundThe body rounds index (BRI), an innovative obesity indicator integrating waist circumference (WC) and height, offers a two-dimensional assessment of obesity. The relationship between BRI trajectories and cancer has been overlooked in previous studies. This study aims to explore the association between BRI trajectories and the incidence of cancer.
methodsThis study included 42,022 participants with a median age of 48.91 years. Based on the changes in participants' BRI during the period from 2006 to 2010, three BRI trajectory patterns were identified: low-stable, medium-stable, and high-stable. The primary outcome was cancer incidence and the secondary outcome was cancer-specific deaths. The association between BRI trajectories and cancer incidence and death was explored by cox regression analysis in the total, sex-specific and age-specific populations, respectively. Additionally, we further investigated the relationship between BRI and site-specific cancer incidence. Sensitivity analyses were applied to exclude interferences and ensure the stability of the results.
resultsAfter a median follow-up time of 11.04 years, high-stable BRI trajectory was significantly associated with increased risk of cancer occurrence compared to low-stable BRI trajectory. This association was more pronounced in middle-aged men (men: HR = 1.46, 95% CI = 1.21-1.77, p < 0.001; age < 65: HR = 11.38, 95% CI = 1.15-1.66, p = 0.001). Additionally, high-stable BRI trajectory was significantly associated with a substantial increase in the risk of site-specific uterine cancers (HR = 4.92, 95% CI = 1.69-14.33, p = 0.004). Sensitivity analysis confirmed the stability of the results.
conclusionOur study identified a significant association between a high-stable BRI trajectory and cancer incidence, with this association being most pronounced in middle-aged men. Moreover, the high-stable BRI trajectory was strongly associated with uterine site-specific cancer development. Our findings underscore the importance of implementing lifestyle modifications and monitoring BRI values and their changes to provide effective health guidance.
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