ArticleInternational journal of clinical pharmacy2025
Exploring the association of adverse drug reactions with medication adherence and quality of life among hypertensive patients: a cross-sectional study.
Article in International journal of clinical pharmacy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Cost-effectiveness of finotonlimab plus bevacizumab versus sorafenib as first-line therapy in unresectable hepatocellular carcinoma in China.Human vaccines & immunotherapeutics · 2026Article
- Mapping Pharmacogenomic Determinants of Adverse Drug Reactions in Hypertension: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Medication Adherence in Relation to Beliefs About Medicines and Health-Related Quality of Life Among Community-Dwelling Patients: A Cross-Sectional Analysis.Journal of evaluation in clinical practice · 2026Article
- Adverse Events Among People Living With HIV Receiving Dolutegravir-Based Regimens: Findings From a 6-Month Active Pharmacovigilance Study in Uganda.Open forum infectious diseases · 2026Article
- A Multi-Framework Approach to Medication Adherence Evaluation in Pharmacy Student-Led Medication Reviews: An Observational Exploratory Study.Pharmacy (Basel, Switzerland) · 2026Article
- Coping strategies for managing medication side effects among patients with chronic diseases in Northwest Ethiopia: An interpretive phenomenological study.Exploratory research in clinical and social pharmacy · 2026Article
- Article
- Potential profiles and associated factors of medication safety competence at home: a study in the older adults following percutaneous coronary intervention.Frontiers in public health · 2026Article
- Analysis of Medication-Related Burden and Associated Factors Among Elderly Patients with Coronary Heart Disease: A Cross-Sectional Study.Patient preference and adherence · 2026Article
- Integrating Network Pharmacology and In Vitro Experiments to Elucidate the Antiatherosclerotic Mechanisms of Qingxin Tongmai Yin.Mediators of inflammation · 2026Article
- Determinants of Medication Non-Adherence in 1,750 Indonesian Adults with Chronic Diseases: A Nationwide Cross-Sectional Study.Patient preference and adherence · 2026Article
- Patient satisfaction and disease-related knowledge in otorhinolaryngology outpatient care in Saudi Arabia.Scientific reports · 2025Article
- Trends in the prevalence of apparent treatment-resistant hypertension among U.S. adults, 1999-2018.American journal of preventive cardiology · 2025Article
- The risk and cost of drug-drug interactions in an older population acutely admitted to hospital in Ireland.International journal of clinical pharmacy · 2025Article
- Analysis of Upper Gastrointestinal Adverse Events Associated with Oral Anticoagulants and Potential Drug Interactions with Cardiovascular Drugs: Exploratory Study Using FDA Adverse Event Reporting System.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Association Between Receiving Medication Information and Adherence to Antihypertensive Medication: Findings from the 2023 Indonesian Health Survey.Patient preference and adherence · 2025Article
- Medication Adherence During Pregnancy: A Hospital-Based Cross-Sectional Study in Bandung, Indonesia.Patient preference and adherence · 2025Article
- Effectiveness of an amlodipine and perindopril arginine-based strategy for hypertension management in Morocco: a prospective observational study.The Pan African medical journal · 2025Observational
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundEffective hypertension management requires medication adherence to prevent complications. However, adverse drug reactions (ADRs) can undermine adherence and negatively affect patients' quality of life. Limited research has explored the association between ADRs, medication adherence, and health-related quality of life (HRQoL) in individuals with hypertension.
aimTo investigate the association between ADRs, medication adherence, and HRQoL among patients with hypertension.
methodA cross-sectional study using telephone interviews and medical record reviews was conducted in 11 primary care facilities in Indonesia. The causality of reported ADRs was assessed using the Naranjo algorithm, validated by a panel of experts in pharmacy practice and medication safety. The severity of ADRs was classified using the Hartwig scale. Adherence to antihypertensive drugs was estimated using the Medication Adherence Report Scale-5 (MARS-5). The EuroQoL EQ-5D-5L was used to measure HRQoL. The association between ADRs and medication adherence was assessed using multivariate logistic regression, while the association with HRQoL was evaluated through the Tobit regression model.
resultsA total of 507 patients were included in this study. We found that 20.32% (n = 103) of the patients experienced ADRs, with the most commonly reported ADRs being polyuria and urgency, gastrointestinal symptoms, leg swelling, dizziness/hypotension, palpitations, and dry cough. The majority experienced mild ADRs (n = 75, 72.82%), while 27.18% (n = 28) had reactions of moderate severity. Experiencing ADRs was associated with reduced medication adherence (adjusted odds ratio (OR) 7.15, 95% CI 4.07-12.55) and decreased HRQoL (coefficient: - 0.037).
conclusionPatients experiencing ADRs were seven times more likely to be non-adherent to their medication regimen and reported a reduced quality of life compared to those without ADRs, placing them at a higher risk of suboptimal treatment outcomes. This finding highlights the need for additional monitoring and education for patients affected by ADRs, particularly through more frequent clinical and laboratory assessments, timely management of ADRs, and personalized education on the importance of adherence to prevent hypertension-related complications.
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