Evidence map›Paper›PMID 39607749›Full record

ArticleeLife2024

CPT1A mediates radiation sensitivity in colorectal cancer.

Zhenhui Chen, Lu Yu, Zhihao Zheng, Xusheng Wang, Qiqing Guo, Yuchuan Chen, Yaowei Zhang, Yuqin Zhang, Jianbiao Xiao, Keli Chen and 2 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. The emerging metabolic role and treatment target of CPT1A in CRC.Frontiers in cell and developmental biology · 2026
    Review
  7. Review
  8. Article
  9. Reprogramming of fatty acid metabolism in thyroid cancer: Potential targets and mechanisms.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhenhui Chen *Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Lu Yu *Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4073-3842
Zhihao Zheng *Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xusheng WangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Qiqing GuoDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yuchuan ChenState Key Laboratory of Organ Failure Research, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangdong Provincial Clinical Research Center for Viral Hepatitis, Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yaowei ZhangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Yuqin ZhangDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Jianbiao XiaoDepartment of Pathology, Nanfang Hospital and School of Basic Medical Science, Southern Medical University, Guangzhou, China.
Keli ChenHuiQiao Medical Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Hongying FanDepartment of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.
Yi DingDepartment of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-5035-9255

Funding

Key Science and Technology Brainstorm Project of Guangzhou 202206010045National Natural Science Foundation of China 32070118National Natural Science Foundation of China 32300085National Natural Science Foundation of China 32370139National Natural Science Foundation of China 82273564
6 · The paper itself

Abstract

The prevalence and mortality rates of colorectal cancer (CRC) are increasing worldwide. Radiation resistance hinders radiotherapy, a standard treatment for advanced CRC, leading to local recurrence and metastasis. Elucidating the molecular mechanisms underlying radioresistance in CRC is critical to enhance therapeutic efficacy and patient outcomes. Bioinformatic analysis and tumour tissue examination were conducted to investigate the

Indexed as

Colorectal NeoplasmsRadiation ToleranceAnimalsCarnitine O-PalmitoyltransferaseCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMiceReactive Oxygen SpeciesCarnitine O-PalmitoyltransferaseReactive Oxygen Speciescancer biologycolorectal cancer cellsCPT1AFOXM1humanmouseradiosensitivityreactive oxygen species

Identifiers

PMID39607749
PMCPMC11604221

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.