ArticleMagnetic resonance in medicine2025
Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR Spin TomogrAphy in Time-Domain (MR-STAT) with cerebrospinal fluid suppression.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Feasibility of angiographic imaging using fast 3D Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT).Magma (New York, N.Y.) · 2026Article
- Mapping Neurodegenerative Changes in Clinically Uncertain Parkinsonian Syndrome Patients Using Fast MR Spin TomogrAphy in Time-Domain (MR-STAT) Relaxometry at 3T.Journal of magnetic resonance imaging : JMRI · 2026Article
- Time-efficient, high-resolution 3T whole-brain relaxometry using Cartesian 3D MR Spin TomogrAphy in Time-Domain (MR-STAT) with cerebrospinal fluid suppression.Magnetic resonance in medicine · 2025Article
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Authors and funding
7 authors.
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Abstract
purposeCurrent three-dimensional (3D) MR Spin TomogrAphy in Time-Domain (MR-STAT) protocols use transient-state, gradient-spoiled gradient-echo sequences that are prone to cerebrospinal fluid (CSF) pulsation artifacts when applied to the brain. This study aims to develop a 3D MR-STAT protocol for whole-brain relaxometry that overcomes the challenges posed by CSF-induced ghosting artifacts.
methodWe optimized the flip-angle train within the Cartesian 3D MR-STAT framework to achieve two objectives: (1) minimization of the noise level in the reconstructed quantitative maps, and (2) reduction of the CSF-to-white-matter signal ratio to suppress CSF-associated pulsation artifacts. The optimized new sequence was tested on a gel/water phantom for accuracy evaluation of the quantitative maps, and on healthy volunteers to explore the effectiveness of the CSF artifact suppression and robustness of the new protocol.
resultsAn optimized sequence with high parameter-encoding capability and low CSF signal response was proposed and validated in the gel/water phantom experiment. From in vivo experiments with 5 volunteers, the proposed CSF-suppressed sequence produced quantitative maps with no CSF artifacts and showed overall greatly improved image quality compared with the baseline sequence. Statistical analysis indicated low intersubject and interscan variability for quantitative parameters in gray matter and white matter (1.6%-2.4% for T
conclusionWe present a new 3D MR-STAT sequence with CSF suppression that effectively eliminates CSF pulsation artifacts. The new sequence ensures consistently high-quality, 1-mm
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