Evidence map›Paper›PMID 39609656›Full record

ArticleJournal of nanobiotechnology2024

Biomimetic mesenchymal stem cell membrane-coated nanoparticle delivery of MKP5 inhibits hepatic fibrosis through the IRE/XBP1 pathway.

Yafei Tian, Dandan Sun, Na Liu, Jianan Zhao, Tongjian Zhao, Xiaonan Liu, Xinzhe Dong, Li Dong, Wei Wang, Ping Jiao and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yafei TianSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Dandan SunSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Na LiuSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Jianan ZhaoSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Tongjian ZhaoSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Xiaonan LiuSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Xinzhe DongSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Li DongSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Wei WangSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China.
Ping JiaoSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China. Jiao_Ping@jlu.edu.cn.
Jie MaSchool of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun, 130021, Jilin, China. Ma_Jie@jlu.edu.cn.

Funding

Jilin Province Development and Reform Commission 2022C014Natural Science Foundation of Jilin Province 3D5242534432Research Initiation Fund of Jilin University 419080600207
6 · The paper itself

Abstract

Hepatic fibrosis is a common disease with high morbidity and mortality rates. The complex and poorly understood mechanisms underlying hepatic fibrosis represent a significant challenge for the development of more effective therapeutic strategies. MKP5 is a potential regulator of multiple fibrotic diseases. However, its precise role and mechanism of action in hepatic fibrosis remains unclear. This study identified a reduction in MKP5 expression in fibrotic liver tissues of mice treated with CCl

Indexed as

Liver CirrhosisMesenchymal Stem CellsMice, KnockoutNanoparticlesSignal TransductionX-Box Binding Protein 1AnimalsApoptosisCarbon TetrachlorideCell MembraneEndoribonucleasesHepatic Stellate CellsHepatocytesHumansLiverMaleCarbon TetrachlorideEndoribonucleasesErn1 protein, mouseProtein Serine-Threonine KinasesX-Box Binding Protein 1Xbp1 protein, mouseHepatic fibrosisHepatocytes apoptosisHSCs activationMKP5Nano-delivery system, Mesenchymal stem cell membrane

Identifiers

PMID39609656
PMCPMC11606114

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.