SynthesisJournal of orthopaedic surgery and research2024
The association between interleukin-8 gene polymorphism and the risk of sepsis in older adults.
Synthesis in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Microbiologic analysis of 140 patients undergoing revision total knee arthroplasty due to periprosthetic joint infection and aseptic loosening: droplet digital PCR analysis.Journal of orthopaedic surgery and research · 2025Article
- Mid-term results after DAIR for patients with acute periprosthetic joint infections of the hip or knee.Journal of orthopaedic surgery and research · 2025Article
- Identification of Co-Diagnostic Genes and Potential Therapeutic Targets for Asthma and Sepsis Through Mendelian Randomization and Immune Infiltration Analysis.Journal of asthma and allergy · 2025Article
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4 authors.
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Abstract
backgroundPrevious studies on the relationship between interleukin-8 (IL-8) rs4073 polymorphism and sepsis susceptibility have covered contradictory results. Our purpose is to investigate whether this polymorphism confers a risk for sepsis using both experimental methods and meta-analysis.
methodsIn the current study, the authoritative databases including PubMed and Embase were carefully searched and reviewed. The search period spanned from the inception of each database until June 2024. Odds ratio (OR) and 95% confidence interval (CI) were adopted to compute the association strength. A total of 480 patients and 840 healthy individuals in older adults were selected. PCR-RFLP was applied to investigate the gene polymorphism including genotype frequency and allele frequency.
resultsIn summary, no significant association was found by allele contrast (T vs. A: OR = 1.11, 95% CI = 0.75-1.62, P = 0.606), homozygote comparison (TT vs. AA: OR = 1.35, 95% CI = 0.57-3.20, P = 0.498), heterozygote comparison (AT vs. AA: OR = 1.38, 95% CI = 0.72-2.65, P = 0.668), recessive genetic model (TT vs. AA/TA: OR = 0.96, 95% CI = 0.64-1.43, P = 0.834), or dominant genetic model (TT/TA vs. AA: OR = 1.37, 95% CI = 0.68-2.79, P = 0.380). Analysis of the IL-8 gene polymorphism revealed three genotypes: AA, TA, and TT. We found that TT genotype and T allele were significantly associated with sepsis risk in older adults (all p < 0.05).
conclusionThe meta-analysis indicates no positive findings. However, the present experimental study has demonstrated that the IL-8 rs4073 polymorphism contributes increased risk to sepsis for older adults from Zhejiang Province, China. Future studies are urgently needed to confirm our conclusion.
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