Evidence map›Paper›PMID 39609811›Full record

ArticleJournal of nanobiotechnology2024

Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochondrial energy recovery to drive the treatment of inflammatory bowel disease.

Manxiu Huai, Mingliang Pei, Jie Chen, Xiaoyan Duan, Yun Zhu, Fan Yang, Wensong Ge

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Manxiu Huai *Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, P. R. China.
Mingliang Pei *Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. pei1991@sjtu.edu.cn.
Jie ChenShanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, No.241 West Huaihai Road, Shanghai, 200030, P. R. China.
Xiaoyan DuanDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, P. R. China.
Yun ZhuDepartment of Oral and Maxillofacial Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Fan YangDepartment of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. yf12498@sjtu.edu.cn.
Wensong GeDepartment of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Shanghai, 200092, P. R. China. gewensong@xinhuamed.com.cn.

Funding

China Postdoctoral Science Foundation 2021M692433National Natural Science Foundation of China 81200279Natural projects for basic research of Shanghai Chest Hospital 2020YNJCQ12Science and Technology Commission of Shanghai Municipality Scientific and Innovative Action Plan of Shanghai (CN) 21142202200Shanghai Post-Doctoral Excellence Program 2020408
6 · The paper itself

Abstract

The damnification of mitochondrion is often considered to be an important culprit of inflammatory bowel disease (IBD), however, there are fewer reports of mechanisms of mitochondria-mediated IBD treatment. Therefore, we first proposed to reboot mitochondrial energy metabolism to treat IBD by capturing the double-sided factor of ROS and creatine (Cr)-assisted energy adjustment. Herein, an oral Cr-modified selenium-based hyaluronic acid (HA) nanogel (HA

Indexed as

CreatineEnergy MetabolismHyaluronic AcidInflammatory Bowel DiseasesMitochondriaNanogelsSeleniumAdministration, OralAnimalsHumansMaleMicePolyethylene GlycolsPolyethyleneimineRAW 264.7 CellsReactive Oxygen SpeciesCreatineHyaluronic AcidNanogelspolyethylene glycol polyethyleneimine nanogelPolyethylene GlycolsPolyethyleneimineReactive Oxygen SpeciesSeleniumEnergy adjustmentIBD treatmentMitochondrial repairNanogelROS scavenging

Identifiers

PMID39609811
PMCPMC11603945

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.