Evidence map›Paper›PMID 39609829›Full record

SynthesisBMC endocrine disorders2024

Cognitive changes in people with diabetes with lower extremity complications compared to people with diabetes without lower extremity complications: a systematic review and meta-analysis.

Nimantha Karunathilaka, Christina Parker, Peter A Lazzarini, Pamela Chen, Chloe Katsanos, Margaret MacAndrew, Kathleen Finlayson

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nimantha KarunathilakaCenter for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia. nimantha.durage@hdr.qut.edu.au.
Christina ParkerCenter for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia.
Peter A LazzariniCenter for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia.
Pamela ChenJoondalup Health Campus, Ramsay Healthcare, Perth, WA, Australia.
Chloe KatsanosPodiatry Department, The Alfred, Melbourne, VIC, Australia.
Margaret MacAndrewCenter for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia.
Kathleen FinlaysonCenter for Healthcare Transformation, Queensland University of Technology, Brisbane, QLD, Australia.

Funding

Queensland University of Technology QUT Postgraduate Research Award and QUT Higher Degree Research tuition fee scholarships.
6 · The paper itself

Abstract

backgroundRecent evidence suggests that diabetes-related lower-extremity complications (DRLECs) may be associated with cognitive changes in people with diabetes. However, existing literature has produced inconsistent findings, and no systematic reviews have been conducted to investigate whether DRLECs impact the cognition of people with diabetes. This systematic review evaluated existing studies that investigated cognition in people with diabetes with DRLECs and without DRLECs.

methodSeven databases; MEDLINE, PubMed, CINAHL, EMBASE, Cochrane, PsycINFO and Web of Science were searched from inception until 22/8/2022 for studies that compared cognition in people with diabetes with and without DRLECs. Results were independently screened for eligibility and assessed for methodological quality by two authors, with key data extracted. Studies were eligible for meta-analysis if the studies reported similar cases, controls, and outcome measures.

resultsThirteen studies were included in the review, with eleven of medium methodological quality, one of high quality, and one of low quality. Four studies found significant differences in cognition between those with and without DRLECs, four found significant associations between diabetes-related lower-extremity complications and cognition, and five found no differences or associations. One small meta-analysis of eligible studies found that there was no statistically significant difference in cognition in people without, compared to with, peripheral neuropathy (Mean difference = -0.49; 95%CI: -1.59-0.61; N = 3; n = 215). Leave-one-out sensitivity analyses further confirmed that there was no significant difference in cognition among people with and without peripheral neuropathy (p > 0.05).

conclusionDRLECs may be related to cognition in people with diabetes, however, existing evidence is unclear due to variability in used methodologies that may challenge concluding the findings. Future high-quality studies investigating cognition among people with and without DRLECs are needed.

Indexed as

Diabetes ComplicationsLower ExtremityCognitionCognitive DysfunctionDiabetes MellitusDiabetic NeuropathiesHumansCognitionDiabetes complicationsDiabetes mellitusDiabetic footMeta-analysisSystematic review

Identifiers

PMID39609829
PMCPMC11605952

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.