Evidence map›Paper›PMID 39610293›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Exposure duration and cerebral amyloidosis in the olfactory cortex of World Trade Center responders: A positron emission tomography and magnetic resonance imaging study.

Minos Kritikos, Juin-Wan Zhou, Chuan Huang, Sam Gandy, Alison C Pellecchia, Stephanie Santiago-Michels, Melissa A Carr, Shabab Islam, Yuan Yang, Megan K Horton and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Minos KritikosProgram in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Health Sciences Center, Stony Brook, NY, USA.
Juin-Wan ZhouDepartment of Biomedical Engineering, Stony Brook University, Health Sciences Center, Stony Brook, NY, USA.
Chuan HuangDepartment of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA.
Sam GandyDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alison C PellecchiaStony Brook World Trade Center Health and Wellness Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Stephanie Santiago-MichelsThe Graduate Center and Queens College, City University of New York, New York, NY, USA.
Melissa A CarrStony Brook World Trade Center Health and Wellness Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Shabab IslamStony Brook World Trade Center Health and Wellness Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.
Yuan YangProgram in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Health Sciences Center, Stony Brook, NY, USA.ORCID 0000-0003-2138-5811
Megan K HortonDepartment of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Roberto G LucchiniDepartment of Environmental Health Sciences, Robert Stempel College of Public Health and Social Work, Florida International University, Miami, FL, USA.ORCID 0000-0002-9723-0237
Ana M FranceschiDepartment of Radiology, Northwell Health, New York, NY, USA.
Lev BangiyevDepartment of Radiology, Renaissance School of Medicine at Stony Brook University, Health Sciences Center, Stony Brook, NY, USA.
Paul VaskaDepartment of Biomedical Engineering, Stony Brook University, Health Sciences Center, Stony Brook, NY, USA.
Sean Ap CloustonProgram in Public Health and Department of Family, Population, and Preventive Medicine, Renaissance School of Medicine at Stony Brook University, Health Sciences Center, Stony Brook, NY, USA.ORCID 0000-0002-6124-0329
Benjamin J LuftStony Brook World Trade Center Health and Wellness Program, Renaissance School of Medicine at Stony Brook University, Stony Brook, NY, USA.

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
A lifecourse approach to PTSD and cognitive aging: A cohort of 9/11 respondersR01AG049953 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI CLOUSTON, SEAN · 2015 to 2024
$11.0M
Burden and change in Alzheimers disease neuropathology in aging World Trade Center respondersR01AG067590 · NIA · STATE UNIVERSITY NEW YORK STONY BROOK · PI CLOUSTON, SEAN, KUAN, PEI-FEN · 2021 to 2025
$4.0M
NIA NIH HHS P30 AG066514NIA NIH HHS R01 AG049953NIA NIH HHS R01 AG067590NIOSH CDC HHS U01 OH011314
6 · The paper itself

Abstract

backgroundAmyloid-β proteins, a hallmark of Alzheimer's disease, are believed to play an adaptive role in the cerebral immune response.

objectiveAmyloid is believed to play a role in cerebral immune response and could play a similar role in response to air pollution exposures. In the present study, we examined whether WTC exposure duration was associated with cerebral amyloidosis in WTC responders.

methodsWTC responders (aged 44-65 years) who varied in exposure duration but did not use personalized protective equipment were assessed using positron-emission tomography with [

resultsThe mean age of imaged responders was 56 years old. WTC exposure duration was associated with olfactory [

conclusionsLow-grade amyloidosis in the olfactory and frontal lobes was associated with WTC exposure duration. Future work should examine whether low-grade amyloidosis is correlated with the location or distribution of neurofibrillary tangles in WTC responders.

Indexed as

AmyloidosisOccupational ExposureOlfactory PathwaysSeptember 11 Terrorist AttacksAdultAgedAniline CompoundsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyStilbenesTime Factors4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbeneAniline CompoundsStilbenesAlzheimer's diseaseamyloidosiscognitive impairmentfirst respondersWorld Trade Center

Identifiers

PMID39610293
PMCPMC12261283

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.