Evidence map›Paper›PMID 39610754›Full record

ArticleJACS Au2024

C2-Linked Arabinose-Functionalized Polystyrene Microbeads Selectively Target

Gulab Walke, Cristina Santi, Calum Haydon, Pooja Joshi, Yuiko Takebayashi, Sylvain Rama, Josephine Dorh, Srinivas Hotha, James Spencer, M Carmen Galan

Abstract read
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Gulab WalkeSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.
Cristina SantiSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.
Calum HaydonSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.
Pooja JoshiDepartment of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411 008, India.
Yuiko TakebayashiSchool of Cellular and Molecular Medicine, University of Bristol Biomedical Sciences Building, Bristol BS8 1TD, United Kingdom.
Sylvain RamaFluoretiQ Ltd., Futurespace, Filton Road, Stoke Gifford, Bristol BS34 8RB, United Kingdom.
Josephine DorhFluoretiQ Ltd., Futurespace, Filton Road, Stoke Gifford, Bristol BS34 8RB, United Kingdom.
Srinivas HothaDepartment of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411 008, India.ORCID https://orcid.org/0000-0003-4159-8590
James SpencerSchool of Cellular and Molecular Medicine, University of Bristol Biomedical Sciences Building, Bristol BS8 1TD, United Kingdom.ORCID https://orcid.org/0000-0002-4602-0571
M Carmen GalanSchool of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, United Kingdom.ORCID https://orcid.org/0000-0001-7307-2871

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbohydrates play pivotal roles in the first stages of microbial infections and can be exploited as decoys to hijack the interactions between bacteria and the host cell. Multivalent glycan probes mimicking the natural presentation of glycans in living cells have been successfully employed to study fundamental carbohydrate/protein interactions in microbial systems; however, most pathogenic glycan receptors exhibit a shared specificity for commonly found sugars present in both healthy and pathogenic cells, posing a challenge for target selectivity. In this study, we report the synthesis of a small library of d-arabinose multivalent probes, a sugar absent in human physiology, and their evaluation in a bacteria agglutination assay using cluster analysis. Our findings reveal preferential binding to

Identifiers

PMID39610754
PMCPMC11600162

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.