ArticleAsian Pacific journal of cancer prevention : APJCP2024
Effects of Conjugated Linoleic Acid (CLA) Supplementation and Exposure of Cigarette Smoke on Bcl-2, P53 Protein, and TNF-α Expression in the Epitels of Wistar Rats (Rattus Norvegicus) Bladder.
Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the effect of Conjugated Linoleic Acid (CLA) supplementation on Bcl-2, P53 protein and TNF- α expression in the bladder of rats which is exposed to cigarette smoke. <br /><br />Methods: The study is a true experimental in Wistar rats. Sample was divided into 4 groups: group A had a 0.5% CLA supplementation (125 mg) diet, group B had a 1% of CLA diet (250mg). 2 other was control groups group without CLA supplementation (group C) as positive control and without cigarette smoke exposure and group D as negative control. The study takes 60 days of exposure and then Bcl-2, P53 protein and TNF- α expression on bladder epithelial was evaluated by immunohistochemistry staining. Data analysis was then performed using the One-way ANOVA test.<br /><br />Result: It showed that rats in group C has an average Bcl-2 expression of 25.8±7.33%, while Group B obtained an average Bcl-2 expression was 14.2±9.6% and had a significant difference when compared to group C (p=0.032). TNF-α expression in the four groups showed that TNF- α expression in group C was the highest with an average of 87.80±8.20. For TNF- α group B of 28.80±13.88 expression has a significant difference when compared to group C (p=0.000). Increase expression of wild-type p53 in group B compared to group A and decrease expression of wild type p53 in groups C and D compared to group B. Meanwhile, mutant type p53 expression showed no expression in all study groups. <br /><br />Conclusion: Exposure of cigarette smoke can increase the expression of Bcl-2, P53 protein and TNF- α in the bladder mucosa and CLA supplementation can reduce Bcl-2, wild-type P53 protein and TNF- α expression.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.