ArticleSleep & breathing = Schlaf & Atmung2024
The association between chemosensitivity and the 10-year risk of type 2 diabetes in male patients with obstructive sleep apnea.
Article in Sleep & breathing = Schlaf & Atmung, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeObstructive sleep apnea (OSA) is associated with a variety of diseases, including type 2 diabetes (T2D). Chemosensitivity is an important component of the pathophysiological mechanisms of OSA, and it is not only elevated in patients with OSA but also in those with T2D. This study aimed to investigate the association between chemosensitivity and the risk of developing T2D in patients with OSA.
methodsA total of 135 male participants with OSA and without pre-existing T2D were enrolled in this study. Peripheral chemosensitivity was evaluated using the rebreathing test. Data on demographics, polysomnographic parameters, and clinical characteristics were collected. The QDiabetes-2018 risk calculator was employed to calculate the 10-year T2D risk. The association between peripheral chemosensitivity and 10-year T2D risk was examined using multivariate logistic regression.
resultsA total of 64 participants had moderate-to-high 10-year risk of T2D. In the fully adjusted model, participants situated within the second and fifth quantiles of peripheral chemosensitivity levels demonstrated a higher risk of developing T2D, with OR of 4.87 (95% CI, 1.22-19.43) and 5.26 (95% CI, 1.27-21.68) respectively. However, across varying levels of peripheral chemosensitivity, no significant difference in the 10-year T2D risk was observed among different severities of OSA.
conclusionHigher peripheral chemosensitivity was associated with an increased 10-year T2D risk, as calculated using a risk calculator based on clinical variables. For outcomes that reflect a moderate-to-high 10-year risk of T2D, the severity of OSA did not significantly affect the risk, irrespective of whether patients exhibited relatively low or high chemosensitivity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.