Evidence map›Paper›PMID 39612052›Full record

ArticleEJNMMI research2024

Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer.

Catherine A Foss, Flonné Wildes, Delia Mezzanzanica, Franca Podo, Chien-Fu Hung, Santosh Yadav, Marie-France Penet Vidaver

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Catherine A FossDepartment of Radiology and Radiological Science, The Russell H. Morgan, Johns Hopkins School of Medicine, Baltimore, MD, USA. cfoss1@jhmi.edu.ORCID http://orcid.org/0000-0001-8870-5993
Flonné WildesDepartment of Radiology and Radiological Science, The Russell H. Morgan, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Delia MezzanzanicaDepartment of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Amadeo 42, Milano, 20133, Italy.
Franca PodoCore Facilities, Istituto Superiore di Sanità, Rome, Italy.
Chien-Fu HungDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Santosh YadavDepartment of Radiology and Radiological Science, The Russell H. Morgan, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Marie-France Penet VidaverDepartment of Radiology and Radiological Science, The Russell H. Morgan, Johns Hopkins School of Medicine, Baltimore, MD, USA. mpenet2@jhmi.edu.

Funding

Emerson Collective Emerson CollectiveSidney Kimmel Comprehensive Cancer Center Cancer Molecular and Functional Imaging Program
6 · The paper itself

Abstract

backgroundTumor-Associated Macrophages (TAMs) play a critical role in the pathogenesis and progression of ovarian cancer, a lethal gynecologic malignancy. [

resultsPET/MRI data show an intense ring of radiotracer uptake surrounding primary tumors. PET uptake is also associated with lung metastases, but not healthy lung. Mice displaying ascites also display PET uptake along the gastrointestinal tract while sham-operated mice show minimal gastrointestinal uptake. All mice show specific kidney uptake. Mice imaged by NIRF confirmed TAMs uptake mostly at the rim of primary tumors while 1 mm secondary tumors in the lungs displayed robust, homogeneous uptake of the radio- and fluorescent analog. Ex vivo biodistribution of [

conclusion[

Indexed as

AscitesID8-Defb29-VEGFiodo-DPA-713MacrophagesOvarian cancerTAMs

Identifiers

PMID39612052
PMCPMC11607259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.