Evidence map›Paper›PMID 39612082›Full record

ArticleEuropean geriatric medicine2025

Cross-sectional and longitudinal associations between glycaemic measures and grip strength in people without diabetes in the UK Biobank cohort study.

Antoneta Granic, Rachel Cooper, Christopher Hurst, Susan J Hillman, Richard M Dodds, Miles D Witham, Avan A Sayer

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Article in European geriatric medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Antoneta GranicAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK. antoneta.granic@newcastle.ac.uk.ORCID 0000-0001-9247-899X
Rachel CooperAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK.
Christopher HurstAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK.
Susan J HillmanAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK.
Richard M DoddsAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK.
Miles D WithamAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK.
Avan A SayerAGE Research Group, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, The Health Innovation Neighbourhood, Biomedical Research Building, Newcastle Upon Tyne, NE4 5PL, UK.

Funding

NIHR Newcastle Biomedical Research Centre NIHR203309
6 · The paper itself

Abstract

purposeTo investigate associations between glycaemic measures (HbA1c, random glucose), and grip strength (GS) in adults without prevalent diabetes.

methodsWe included 381,715 UK Biobank participants aged 38-73 years without diabetes (any type) with complete baseline measures for GS and HbA1c (main analyses), and glucose (supplementary analyses). Cross-sectional sex- and age-stratified associations between each glycaemic measure, GS, and probable sarcopenia (low GS) were examined with regression analyses. Changes in GS over 8.9 years were classified into four groups (decline, stable low, stable high, or reference (increase or maintained within the normal range)) in 36,228 participants and associations with baseline glycaemic measures explored using multinomial regression.

resultsHigher HbA1c (mmol/mol) was associated with weaker mean GS (kg) (regression coefficient and 95% confidence intervals (CI): - 0.08 (- 0.09, - 0.07)), and increased odds of probable sarcopenia (odds ratio (OR) and 95% CIs: 1.02 (95% CI: 1.01, 1.02)) in males and across the age groups. In females, higher HbA1c was associated with weaker mean GS only in mid-life (e.g., 50-59 years: - 0.06 (- 0.07, - 0.05)). In males, but not in females with repeated GS, higher HbA1c was associated with decreased odds of stable high (0.97 (0.96, 0.99) and increased odds of stable low (1.03 (1.01, 1.04)) GS pattern (0.98 (0.97, 0.980)) over the follow-up. The results for glucose in supplementary analyses were mixed, especially in females.

conclusionsThe associations between HbA1c and GS in people without diabetes warrant replication and consideration of the effect on muscle strength when interventions to promote normoglycaemia are trialled.

Indexed as

Blood GlucoseGlycated HemoglobinHand StrengthSarcopeniaAdultAgedBiological Specimen BanksCohort StudiesCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedUK BiobankUnited KingdomBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanCohort studyGlycaemic measuresGrip strengthProbable sarcopenia

Identifiers

PMID39612082
PMCPMC11850503

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.