Evidence map›Paper›PMID 39612133›Full record

ArticlePharmacological reports : PR2025

Novel fluorinated cannabinoid analogs modulate cytokine expression in human C20 microglial cells.

Randall L Davis, Sascha Grotjahn, Burkhard Koenig, Daniel J Buck, Jimmie D Weaver

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Randall L DavisDepartment of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, 1111 W. 17th Street, Tulsa, OK, 74107, USA. randall.davis@okstate.edu.
Sascha GrotjahnInstitut für Organische Chemie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.
Burkhard KoenigInstitut für Organische Chemie, Universität Regensburg, Universitätsstraße 31, 93053, Regensburg, Germany.
Daniel J BuckDepartment of Pharmacology and Physiology, Oklahoma State University Center for Health Sciences, 1111 W. 17th Street, Tulsa, OK, 74107, USA.
Jimmie D WeaverDepartment of Chemistry, Oklahoma State University, 107 Physical Sciences, Stillwater, OK, 74078, USA.

Funding

Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to SynthesisR35GM139613 · NIGMS · OKLAHOMA STATE UNIVERSITY STILLWATER · 2022 to 2025
$1.4M
Deutsche Forschungsgemeinschaft (German Science Foundation) GRK 2620 - 426795949NIGMS NIH HHS R35 GM139613NIH HHS R35GM139613
6 · The paper itself

Abstract

backgroundPhytochemicals derived from the plant Cannabis sativa hold promise in terms of medicinal value. Cannabinoids such as Δ

methodsHerein, we describe four novel cannabinoids (a deoxy trifluoroCBN analog (F

resultsThe cannabinoids examined had minimal to no effect on metabolic activity up to 10 µM. Notably, F

conclusionsThese findings are foundational for new lines of investigation into the therapeutic potential of four novel fluorinated cannabinoids.

Indexed as

CannabinoidsCytokinesMicrogliaCell LineDronabinolHalogenationHumansCannabinoidsCytokinesDronabinolCannabinoidsChemokineCytokineFluorinatedInflammatoryMicroglia

Identifiers

PMID39612133
PMCPMC12094157

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.