Evidence map›Paper›PMID 39612137›Full record

SynthesisOdontology2025

Does non-surgical periodontal treatment contribute to rheumatoid arthritis amelioration? Evidence based on an overview and meta-analysis.

Sicília Rezende Oliveira, José Alcides Almeida de Arruda, Ayda Henriques Schneider, Gilda Aparecida Ferreira, Débora Cerqueira Calderaro, Fernando Oliveira Costa, Antonio Lucio Teixeira, Renê Donizeti Ribeiro de Oliveira, Paulo Louzada-Júnior, Fernando Queiroz Cunha and 2 more

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Odontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sicília Rezende OliveiraDepartment of Oral Surgery, Pathology, and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Room 3204, Belo Horizonte, Minas Gerais, Brazil.
José Alcides Almeida de ArrudaDepartment of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.
Ayda Henriques SchneiderDepartment of Pharmacology, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Gilda Aparecida FerreiraDepartment of Locomotor Apparatus, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Débora Cerqueira CalderaroDepartment of Locomotor Apparatus, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Fernando Oliveira CostaDepartment of Oral Surgery, Pathology, and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Room 3204, Belo Horizonte, Minas Gerais, Brazil.
Antonio Lucio TeixeiraDepartment of Psychiatry and Behavioral Sciences, Neuropsychiatry Program, The University of Texas Health Science Center at Houston, Houston, USA.
Renê Donizeti Ribeiro de OliveiraDivision of Clinical Immunology, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Paulo Louzada-JúniorDivision of Clinical Immunology, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Fernando Queiroz CunhaDepartment of Pharmacology, Ribeirão Preto Medical School, Universidade de São Paulo, Ribeirão Preto, Brazil.
Lucas Guimarães AbreuDepartment of Child and Adolescent Oral Health, School of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Tarcília Aparecida SilvaDepartment of Oral Surgery, Pathology, and Clinical Dentistry, School of Dentistry, Universidade Federal de Minas Gerais, Av. Pres. Antônio Carlos, 6627, Room 3204, Belo Horizonte, Minas Gerais, Brazil. silva.tarcilia@gmail.com.ORCID http://orcid.org/0000-0001-9623-7835

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico #305077/2021-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo #2013/08216-2
6 · The paper itself

Abstract

The aim of the present study was to provide an overview evaluating the effects of non-surgical periodontal treatment in rheumatoid arthritis, focusing on 28-joint Disease Activity Score (DAS28), C-reactive protein, and erythrocyte sedimentation rate. Systematic reviews, with and without meta-analyses, comparing individuals who had undergone non-surgical periodontal treatment with those who had not, and assessing parameters before and after treatment, were included. Electronic searches were conducted in August 2023 and updated in August 2024 across four databases (PubMed, Scopus, Embase, and Web of Science) and gray literature, with no restriction on language or publication date. The study followed the 2020 PRISMA statement, and a protocol was registered in PROSPERO (CRD42023414714). A total of 10 systematic reviews were included: six with meta-analyses and four without meta-analyses. The number of articles included ranged from three to 31 studies. Non-surgical periodontal treatment resulted in a significant decrease in C-reactive protein, erythrocyte sedimentation rate, and DAS28. The follow-up period after treatment ranged from six to 24 weeks. A meta-analysis was conducted, incorporating data from 18 primary studies identified in the systematic reviews and comparing the difference in DAS28 at baseline (n = 454) and up to three months (n = 449) after the non-surgical periodontal treatment. A significant reduction in DAS28 was observed (MD = - 0.76; 95% CI = - 1.07 to - 0.44). Despite the heterogeneity of data related to rheumatoid arthritis and periodontitis status, non-surgical periodontal treatment can result in a decrease in the concentration of circulating inflammatory mediators and, consequently, in a reduction in DAS28 in rheumatoid arthritis.

Indexed as

Arthritis, RheumatoidBlood SedimentationC-Reactive ProteinHumansSystematic Reviews as TopicC-Reactive ProteinDental scalingMeta-analysisPeriodontal debridementPeriodontitisRheumatoid arthritis

Identifiers

PMID39612137

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.