ArticleScience immunology2024
The redox sensor KEAP1 facilitates adaptation of T cells to chronic antigen stimulation by preventing hyperactivation.
Abstract read
In one paragraph
Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Capicua mediates interleukin-2 withdrawal-induced death of activated CD8Cell insight · 2026Article
- Inflammatory CD4iScience · 2026Article
- BACH2 dosage establishes the hierarchy of stemness and fine-tunes antitumor immunity in CAR T cells.Nature immunology · 2026Article
- Single-Cell Clonal Lineage Tracing Identifies the Transcriptional Program Controlling the Cell-Fate Decisions by Neoantigen-Specific CD8+ T Cells.Cancer immunology research · 2026Article
- Integrating T cell signaling and metabolism to enhance T cell engager responses in solid tumors.Frontiers in immunology · 2026Review
- Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy.Cellular & molecular immunology · 2026Review
- Palmitoylation modulates antitumor immunity.Molecular biology reports · 2025Review
- The challenges and progress of CAR-T cell therapy in the treatment of solid tumors.Molecular and cellular biochemistry · 2025Review
- NRF2 immunobiology in cancer: implications for immunotherapy and therapeutic targeting.Oncogene · 2025Review
- Salvianolic acid A inhibits PRRSV replication via binding to Keap1 to activate the MKRN1-Nrf2-NQO1 pathway.Veterinary research · 2025Article
- Nrf2 drives activation-driven expansion of CD4Cell reports · 2025Article
- Mitochondrial Transfer Between Cancer and T Cells: Implications for Immune Evasion.Antioxidants (Basel, Switzerland) · 2025Review
- The prostacyclin receptor PTGIR is a NRF2-dependent regulator of CD8Nature immunology · 2025Article
- Circulating T cell atlas in Moyamoya disease: insights into immunopathogenesis of cerebrovascular disorders.Journal of neuroinflammation · 2025Article
- The diverse interaction of metabolism, immune response, and viral pathogens.Frontiers in immunology · 2025Review
- The supramolecular polymer-related signature predicts prognosis and indicates immune microenvironment infiltration in gastric cancer.Clinics (Sao Paulo, Brazil) · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Ziang ZhuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0009-0008-4231-7213
Ying LuoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Guohua LouDepartment of Immunology & Microbiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Kiddist YihunieDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-0863-4863
Safuwra WizzardDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1107-8789
Andrew W DeVilbissChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-9739-2543
Sarah MuhChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Chaoyu MaDepartment of Microbiology, Immunology, & Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-5770-5085
Sejal S ShindeDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Jonathan HoarDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Taidou HuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0003-1520-7824
Nu ZhangDepartment of Microbiology, Immunology, & Molecular Genetics, Long School of Medicine, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-9695-210X
Shyam BiswalDepartment of Environmental Health and Engineering, Johns Hopkins School of Public Health, Baltimore, MD 21205, USA.ORCID 0009-0000-5794-3403
Ralph J DeBerardinisChildren's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-2705-7432
Tuoqi WuDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0002-4003-1034
Chen YaoDepartment of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.ORCID 0000-0001-6852-5661
Funding
Program stem-like CD8 T cells to enhance antiviral immunity against chronic viral infectionR01AI158294 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Tuoqi Wu · 2022 to 2026
$2.9MHarnessing Stem-Like CD8 T Cells for Immunotherapies to Eradicate HIV ReservoirsDP2AI154450 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI YAO, CHEN · 2021 to 2025
$2.5MRejuvenating aged T cell immunity by targeting stem cell-like CD8 T cellsR00AG056524 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2019 to 2021
$733kUnderstand the molecular mechanism of age-associated decline in antiviral CD8 T cell immunityR21AG083398 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI WU, TUOQI · 2023 to 2024
$451kNIAID NIH HHS DP2 AI154450NIAID NIH HHS R01 AI158294NIA NIH HHS K99 AG056524NIA NIH HHS R00 AG056524NIA NIH HHS R21 AG083398
Abstract
During persistent antigen stimulation, exhausted CD8
Indexed as
CD8-Positive T-LymphocytesKelch-Like ECH-Associated Protein 1NF-E2-Related Factor 2Oxidation-ReductionAnimalsLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutReceptors, Antigen, T-CellSignal TransductionKeap1 protein, mouseKelch-Like ECH-Associated Protein 1Nfe2l2 protein, mouseNF-E2-Related Factor 2Receptors, Antigen, T-Cell
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.