Evidence map›Paper›PMID 39612808›Full record

ReviewMedical image analysis2025

A survey on deep learning in medical image registration: New technologies, uncertainty, evaluation metrics, and beyond.

Junyu Chen, Yihao Liu, Shuwen Wei, Zhangxing Bian, Shalini Subramanian, Aaron Carass, Jerry L Prince, Yong Du

Abstract readReview
In one paragraph

Review in Medical image analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Attention-Guided TransMorph for Real-Time Tumor Tracking in Cine-MRI.Journal of imaging informatics in medicine · 2026
    Article
  6. Article
  7. Article
  8. [A reweighted graph matching-based algorithm for automatic extraction of corresponding landmarks in medical images].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Insertion Network for Image Sequence Correspondence Building.Proceedings of SPIE--the International Society for Optical Engineering · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junyu ChenDepartment of Radiology and Radiological Science, Johns Hopkins School of Medicine, MD, USA. Electronic address: jchen245@jhmi.edu.
Yihao LiuDepartment of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
Shuwen WeiDepartment of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
Zhangxing BianDepartment of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
Shalini SubramanianDepartment of Radiology and Radiological Science, Johns Hopkins School of Medicine, MD, USA.
Aaron CarassDepartment of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
Jerry L PrinceDepartment of Electrical and Computer Engineering, Johns Hopkins University, MD, USA.
Yong DuDepartment of Radiology and Radiological Science, Johns Hopkins School of Medicine, MD, USA.

Funding

Multi-Modality Quantitiative Imaging for Evaluation of Response to Cancer TherapyU01CA140204 · NCI · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, SOLNES, LILJA · 2011 to 2022
$6.1M
High Energy and Spatial Resolution Multi-Isotope SPECT Imaging of Targeted Alpha-Emitters and their DaughtersU01EB031798 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, FREY, ERIC C. · 2021 to 2025
$3.8M
Hyperspectral Single Photon Imaging of Targeted Alpha-EmittersR01EB031023 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI DU, YONG, GHALY, MICHAEL · 2021 to 2024
$2.7M
OCT and OCTA image processing for retinal assessment of people with MSR01EY032284 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2021 to 2024
$1.8M
3D segmentation and registration of macular SD-OCT for application in MSR01EY024655 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2014 to 2017
$1.6M
NCI NIH HHS U01 CA140204NEI NIH HHS R01 EY024655NEI NIH HHS R01 EY032284NIBIB NIH HHS R01 EB031023NIBIB NIH HHS U01 EB031798
6 · The paper itself

Abstract

Deep learning technologies have dramatically reshaped the field of medical image registration over the past decade. The initial developments, such as regression-based and U-Net-based networks, established the foundation for deep learning in image registration. Subsequent progress has been made in various aspects of deep learning-based registration, including similarity measures, deformation regularizations, network architectures, and uncertainty estimation. These advancements have not only enriched the field of image registration but have also facilitated its application in a wide range of tasks, including atlas construction, multi-atlas segmentation, motion estimation, and 2D-3D registration. In this paper, we present a comprehensive overview of the most recent advancements in deep learning-based image registration. We begin with a concise introduction to the core concepts of deep learning-based image registration. Then, we delve into innovative network architectures, loss functions specific to registration, and methods for estimating registration uncertainty. Additionally, this paper explores appropriate evaluation metrics for assessing the performance of deep learning models in registration tasks. Finally, we highlight the practical applications of these novel techniques in medical imaging and discuss the future prospects of deep learning-based image registration.

Indexed as

Deep LearningImage Processing, Computer-AssistedHumansUncertaintyDeep neural networksImage registrationMedical imaging

Identifiers

PMID39612808
PMCPMC11730935

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.