Evidence map›Paper›PMID 39613160›Full record

ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2025

An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder.

Margaret T Davis, Ruth H Asch, Emily R Weiss, Ashley Wagner, Sarah K Fineberg, Nabeel Nabulsi, David Matuskey, Richard E Carson, Irina Esterlis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Margaret T DavisDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Psychology, Yale University, New Haven, Connecticut; Department of Veteran Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut. Electronic address: margaret.t.davis@yale.edu.
Ruth H AschDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Emily R WeissDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Ashley WagnerDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Sarah K FinebergDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
David MatuskeyDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Irina EsterlisDepartment of Psychiatry, Yale School of Medicine, New Haven, Connecticut; Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut; Department of Psychology, Yale University, New Haven, Connecticut; Department of Veteran Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven, Connecticut.

Funding

Neuroimaging Sciences Training ProgramT32DA022975 · NIDA · YALE UNIVERSITY · PI Graeme F Mason, Rajita Sinha · 2007 to 2026
$5.7M
in vivo investigation of KOR as a marker of BPD and suicide related endophenotypesR01MH131720 · NIMH · YALE UNIVERSITY · PI DAVIS, MARGARET TAYLOR · 2023 to 2025
$2.3M
Dysregulation in mGluR5 as a marker of BPD and suicide related endophenotypesK08MH117351 · NIMH · YALE UNIVERSITY · PI DAVIS, MARGARET TAYLOR · 2018 to 2022
$983k
NIDA NIH HHS T32 DA022975NIMH NIH HHS K08 MH117351NIMH NIH HHS L30 MH120754NIMH NIH HHS R01 MH131720
6 · The paper itself

Abstract

backgroundBorderline personality disorder (BPD) is a serious psychiatric condition that is associated with a high risk for suicide attempts (SAs) and death by suicide. However, relatively little is known about the pathophysiology of BPD. The metabotropic glutamate 5 receptor (mGlu

methodsEighteen individuals with BPD, 18 healthy control participants matched on age, sex, and smoking status, and 18 clinical comparison control participants with major depressive disorder completed comprehensive clinical assessments and participated in an [

resultsWe observed significantly higher frontolimbic mGlu

conclusionsResults show higher mGlu

Indexed as

Borderline Personality DisorderReceptor, Metabotropic Glutamate 5Suicide, AttemptedAdultFemaleHumansMajor Depressive DisorderMalePositron-Emission TomographyYoung AdultGRM5 protein, humanReceptor, Metabotropic Glutamate 5Borderline personality disorderDepressionGlutamatemGlu(5)PETSuicide attempt

Identifiers

PMID39613160
PMCPMC12009513

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.