ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025
Identifying neural circuitry abnormalities in neuropathic pain with transcranial magnetic stimulation and electroencephalogram co-registration.
Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Combining Pulsed Radiofrequency With Transcranial Magnetic Stimulation to Manage Hemiplegic Shoulder Pain and Somatosensory Nerve Transmissions.Pain research & management · 2026Trial
- Article
- Effect of Transcranial Magnetic Stimulation in Patients with Postherpetic Neuralgia and Comorbid Depression: A Randomized Controlled Trial.Pain and therapy · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Association Between Pain Subtypes and Cognitive Impairment in Parkinson's Disease.Journal of pain research · 2026Article
- Concurrent TMS-EEG to characterize cortical responses in the motor and prefrontal cortices in Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- The intrinsic reason why complementary tests (clinical neurophysiology, neuroimaging, skin biopsy) cannot establish the diagnosis of neuropathic pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Extracting reproducible components from electroencephalographic responses to transcranial magnetic stimulation with group task-related component analysis.Imaging neuroscience (Cambridge, Mass.)Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-invasive brain stimulation (NIBS) technology such as transcranial magnetic stimulation (TMS) represents a promising treatment for neuropathic pain. However, neural circuitries underlying analgesia remain to be established, which is largely limiting treatment responses. Using TMS and electroencephalogram co-registration (TMS-EEG), this study quantified the circuitry abnormalities in neuropathic pain and their associations with pain symptoms. A group of 21 neuropathic pain individuals and 21 healthy controls were assessed with TMS-EEG delivering to the primary motor cortex (M1). With source modelling, local current density and current propagation were analysed with significant current density (SCD) and scattering (SCS) respectively. The SCS and SCD data converged on higher activities in neuropathic pain individuals than healthy controls, within the emotional affective (perigenual anterior cingulate cortex, pgACC), sensory nociceptive (primary somatosensory cortex, S1), and the attentional cognitive (anterior insula, aINS; supracallosal anterior cingulate cortex, scACC) structures of pain. Moreover, current propagation to the pgACC was associated with lower pain-related negative emotions, while current propagation to the aINS with higher pain-related negative emotions. Using concurrent TMS-EEG, our data identified abnormal pain circuitries that could be utilised to improve treatment efficacy with brain stimulation technologies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.