Evidence map›Paper›PMID 39613547›Full record

ReviewTrends in endocrinology and metabolism: TEM2025

Lipid droplets as cell fate determinants in skeletal muscle.

Jingjuan Chen, James F Markworth, Christina Ferreira, Chi Zhang, Shihuan Kuang

Abstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jingjuan ChenDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Orthopaedic Surgery, Duke University, Durham, NC 27710, USA.
James F MarkworthDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA.
Christina FerreiraBindley Bioscience Center, Purdue University, West Lafayette, IN 47907, USA.
Chi ZhangDepartment of Chemistry, Purdue University, West Lafayette, IN 47907, USA.
Shihuan KuangDepartment of Animal Sciences, Purdue University, West Lafayette, IN 47907, USA; Department of Orthopaedic Surgery, Duke University, Durham, NC 27710, USA; Purdue University Institute for Cancer Research, West Lafayette, IN 47907, USA. Electronic address: Shihuan.Kuang@duke.edu.

Funding

Immunomyoblasts in muscle regenerationR01AR078695 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2021 to 2025
$2.2M
Metabolic regulation of muscle satellite cell homeostasisR01DK132819 · NIDDK · PURDUE UNIVERSITY · PI Shihuan Kuang · 2023 to 2026
$2.0M
Targeting PTEN to ameliorate muscular dystrophy in a mouse modelR01AR079235 · NIAMS · PURDUE UNIVERSITY · PI KUANG, SHIHUAN · 2022 to 2025
$1.3M
NIAMS NIH HHS R01 AR078695NIAMS NIH HHS R01 AR079235NIDDK NIH HHS R01 DK132819
6 · The paper itself

Abstract

Lipid droplets (LDs) are dynamic organelles that communicate with other cellular components to orchestrate energetic homeostasis and signal transduction. In skeletal muscle, the presence and importance of LDs have been widely studied in myofibers of both rodents and humans under physiological conditions and in metabolic disorders. However, the role of LDs in myogenic stem cells has only recently begun to be unveiled. In this review we briefly summarize the process of LD biogenesis and degradation in the most prevalent model. We then review recent knowledge on LDs in skeletal muscle and muscle stem cells. We further introduce advanced methodologies for LD imaging and mass spectrometry that have propelled our understanding of the dynamics and heterogeneity of LDs.

Indexed as

Lipid DropletsMuscle, SkeletalAnimalsHumansLipid Metabolismlipid dropletslipid mediatorsmuscle stem cellsskeletal muscle

Identifiers

PMID39613547
PMCPMC12116854

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.