Evidence map›Paper›PMID 39613754›Full record

ArticleNature communications2024

Paired analysis of host and pathogen genomes identifies determinants of human tuberculosis.

Yang Luo, Chuan-Chin Huang, Nicole C Howard, Xin Wang, Qingyun Liu, Xinyi Li, Junhao Zhu, Tiffany Amariuta, Samira Asgari, Kazuyoshi Ishigaki and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. HowVaccines · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Genomic landscape ofNew microbes and new infections · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yang Luo *Center for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7385-6166
Chuan-Chin Huang *Division of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA.
Nicole C Howard *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Xin Wang *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-6930-3347
Qingyun Liu *Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-2284-5050
Xinyi LiCommittee on Genetics, Genomics, and Systems Biology, University of Chicago, Chicago, IL, USA.
Junhao ZhuDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA.ORCID 0000-0002-3301-5677
Tiffany AmariutaCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Samira AsgariCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Kazuyoshi IshigakiCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Roger CalderonAdvanced Research and Health, Lima, Peru.ORCID 0000-0001-8932-0489
Sahadevan RamanDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-5309-8169
Alexandrea K RamnarineDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3096-8648
Jacob A MayfieldDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5762-6755
D Branch MoodyDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2306-3058
Leonid LeccaDepartment of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Sarah M FortuneDepartment of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA, USA. sfortune@hsph.harvard.edu.ORCID 0000-0001-7565-9975
Megan B MurrayDivision of Global Health Equity, Brigham and Women's Hospital, Boston, MA, USA. megan_murray@hms.harvard.edu.ORCID 0000-0003-0443-1986
Soumya RaychaudhuriCenter for Data Sciences, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. soumya@broadinstitute.org.ORCID 0000-0002-1901-8265

Funding

Metabolomics Core U19AI111224 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MURRAY, MEGAN B, VANRHIJN, ILDIKO · 2015 to 2021
$20.4M
Gerome Wide Association Study of Bacterial Determinants of Clinical Response in TuberculosisU19AI142793 · NIAID · HARVARD MEDICAL SCHOOL · PI FORTUNE, SARAH · 2019 to 2023
$14.6M
Real-time surveillance to support dynamic and predictive models of MDR/XDR TBU19AI076217 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI FARMER, PAUL EDWARD · 2007 to 2011
$13.5M
Systems Genetics of TuberculosisP01AI132130 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BEHAR, SAMUEL M · 2017 to 2021
$11.2M
Systems Genetics of TuberculosisP01AI181898 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CHRISTOPHER M SASSETTI · 2024 to 2026
$10.5M
Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Epidemiology of Infectious Diseases and BiodefenseT32AI007535 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRAD, YONATAN H, MURRAY, MEGAN B · 1998 to 2025
$4.8M
Chemical Biological Discovery of Lipid Virulence Factors in the Major Bacterial PathogensR01AI165573 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI MOODY, DAVID BRANCH · 2022 to 2025
$3.0M
Functionally specialized components of disease heritability in ENCODE dataU01HG009379 · NHGRI · HARVARD SCHOOL OF PUBLIC HEALTH · PI PRICE, ALKES L, RAYCHAUDHURI, SOUMYA · 2017 to 2021
$2.5M
NHGRI NIH HHS U01 HG009379NIAID NIH HHS P01 AI132130NIAID NIH HHS P01 AI181898NIAID NIH HHS R01 AI165573NIAID NIH HHS T32 AI007535NIAID NIH HHS U19 AI076217NIAID NIH HHS U19 AI111224NIAID NIH HHS U19 AI142793NIAMS NIH HHS R01 AR063759
6 · The paper itself

Abstract

Infectious disease is the result of interactions between host and pathogen and can depend on genetic variations in both. We conduct a genome-to-genome study of paired human and Mycobacterium tuberculosis genomes from a cohort of 1556 tuberculosis patients in Lima, Peru. We identify an association between a human intronic variant (rs3130660, OR = 10.06, 95%CI: 4.87 - 20.77, P = 7.92 × 10

Indexed as

Host-Pathogen InteractionsMycobacterium tuberculosisTuberculosisAdultCohort StudiesCOVID-19FemaleGenome, BacterialHumansMacrophagesMaleMutationPeruPolymorphism, Single NucleotideSARS-CoV-2Thioredoxin-Disulfide ReductaseThioredoxin-Disulfide Reductase

Identifiers

PMID39613754
PMCPMC11607449

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.