Evidence map›Paper›PMID 39614040›Full record

Trial reportGeroScience2025

Effect of transcranial direct current stimulation with cognitive training on executive functions in healthy older adults: a secondary analysis from the ACT trial.

Serkan Aksu, Aprinda Indahlastari, Andrew O'Shea, Michael Marsiske, Ronald Cohen, Gene E Alexander, Steven T DeKosky, Georg A Hishaw, Yunfeng Dai, Samuel S Wu and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in GeroScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Serkan AksuCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA. serkanaksu@mu.edu.tr.ORCID 0000-0001-7715-0320
Aprinda IndahlastariCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA.ORCID 0000-0002-5994-5514
Andrew O'SheaCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA.
Michael MarsiskeCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA.ORCID 0000-0001-5973-2116
Ronald CohenCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA.
Gene E AlexanderDepartment of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, and BIO5 Institute, University of Arizona and Arizona Alzheimer's Disease Consortium, Tucson, AZ, USA.
Steven T DeKoskyCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA.ORCID 0000-0003-3743-2758
Georg A HishawDepartment of Psychiatry, Neuroscience and Physiological Sciences Graduate Interdisciplinary Programs, and BIO5 Institute, University of Arizona and Arizona Alzheimer's Disease Consortium, Tucson, AZ, USA.
Yunfeng DaiDepartment of Biostatistics, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-3961-4766
Samuel S WuDepartment of Biostatistics, College of Public Health and Health Professions, College of Medicine, University of Florida, Gainesville, FL, USA.ORCID 0000-0003-2684-436X
Adam J WoodsCenter for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, 1225 Center Dr, PO Box 100165, Gainesville, FL, 32610, USA.ORCID 0000-0002-0786-0236

Funding

Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Augmenting Cognitive Training in Older Adults - The ACT GrantR01AG054077 · NIA · UNIVERSITY OF FLORIDA · PI COHEN, RONALD A, MARSISKE, MICHAEL · 2016 to 2020
$6.9M
NIA NIH HHS P30 AG072980NIA NIH HHS R01 AG054077
6 · The paper itself

Abstract

Cognitive aging has become a public health concern as the mean age of the population is ever-increasing. It is a naturalistic and common process of degenerative and compensatory changes that may result in neurocognitive disorders. While heterogeneous, cognitive aging mostly affects executive functions that may be associated with functional losses during activities of daily living. Cognition-oriented treatments like cognitive training and transcranial direct current stimulation (tDCS) have garnered considerable attention in the past few decades while the exact picture regarding their efficacy in healthy older adults has not been determined yet. The present paper aimed to evaluate the effects of a 3-month intervention of tDCS over the dorsolateral prefrontal cortex (DLPFC) with multimodal cognitive training on the Stroop test and Trail Making Tests A and B performance. One hundred and ninety-three healthy older adults from 2 sites were administered repeated sessions of active/sham tDCS with cognitive training. Baseline, post-intervention, and 1-year performance results between groups were compared using multiple linear regressions. Active tDCS resulted in better Stroop test performance at post-intervention (p = 0.033) but not at 1-year follow-up while no differences between groups were observed in Trail Making Tests A & B performance. The present results may correspond to a modest improvement in conflict monitoring, potentially due to modulation of prefrontal regions, without changing shifting performance. Further investigation is warranted to draw an interference regarding the subdomain-specific impact of repeated tDCS with multimodal cognitive training on executive functions.

Indexed as

Cognitive AgingCognitive Behavioral TherapyExecutive FunctionTranscranial Direct Current StimulationAgedAged, 80 and overCognitive TrainingDorsolateral Prefrontal CortexFemaleHumansMaleMiddle AgedPrefrontal CortexStroop TestTrail Making TestBrain stimulationCognitive trainingConflict monitoringExecutive functionsOlder adultsTDCSTranscranial direct current stimulation

Identifiers

PMID39614040
PMCPMC11872955

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.