ArticleRespiratory research2024
Association between alcohol consumption and risk of developing tuberculosis in patients with diabetes: a nationwide retrospective cohort study.
Article in Respiratory research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Incidence and predictors of tuberculosis among adult diabetes mellitus patients in western Amhara comprehensive specialized hospitals, northwest Ethiopia. A multicenter retrospective follow-up study.Journal of public health research · 2026Article
- Adverse drug reactions, particularly liver disorders, drive interruptions in anti-tuberculosis treatment: A retrospective cohort study.British journal of clinical pharmacology · 2025Article
- Physical activity intensity and amount are inversely correlated with the risk of tuberculosis in patients with diabetes.Scientific reports · 2025Article
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6 authors.
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Abstract
backgroundDiabetes mellitus (DM) and alcohol consumption are risk factors for tuberculosis (TB). We investigated the association between alcohol consumption and TB development in individuals with type 2 DM (T2DM).
methodsIndividuals who underwent the national health examination during 2009-2012 were screened using the Korean National Health Information Database. In total, 2,437,443 eligible individuals with T2DM were followed up until December 2018. We identified 21,275 individuals with newly developed TB. Alcohol consumption was evaluated based on the health examination questionnaire, and individuals were categorized into none (0 g/day), mild-to-moderate (1-29.9 g/day), and heavy (≥ 30 g/day) drinkers. Multivariate Cox proportional hazard models were used to estimate the adjusted hazard ratio (aHR) of risk factors for TB.
resultsMild-to-moderate alcohol drinkers had a lower risk of developing TB (aHR 0.92, 95% confidence interval [CI] 0.89-0.96), and heavy alcohol drinkers had a higher risk of developing TB (aHR 1.21, 95% CI 1.16-1.27) than nonalcohol drinkers. When categorized by an alcohol intake of 5 g/day, alcohol drinkers of < 5 g/day had the lowest risk (aHR 0.85, 95% CI 0.81-0.90). The risk increased with alcohol intake, resulting in ≥ 20 g/day as the threshold (20-25 g/day, aHR 1.09, 95% CI 1.02-1.16). Stratified analysis revealed that current smokers had an increased risk of developing TB even among mild-to-moderate drinkers.
conclusionsHeavy alcohol consumption has been linked to an increased risk of developing TB in patients with T2DM. In contrast, mild-to-moderate alcohol consumption was associated with a reduced risk of TB, except in current smokers, where it led to a higher risk of TB. The risk of TB substantially increased with alcohol intake of 20 g/day or more, following a J-shaped curve.
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