Evidence map›Paper›PMID 39614764›Full record

ArticleMicroscopy research and technique2025

Revitalizing Muscle Regeneration: Cocoa Polyphenols Shield Mitochondrial Integrity and Boost Myogenesis Under Oxidative Stress.

Jose Angel Garcia-Merino, Vittoria Carrabs, Fabio Ferrini, Sara Salucci, Michela Battistelli, Sabrina Burattini, Francesca Luchetti, Maria Gemma Nasoni, Giosuè Annibalini, Matteo Micucci and 4 more

Abstract read
In one paragraph

Article in Microscopy research and technique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Protective Effects ofPharmaceuticals (Basel, Switzerland) · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jose Angel Garcia-MerinoFaculty of Health Sciences, Universidad Europea de Canarias, La Orotava, Spain.
Vittoria CarrabsDepartamento de Farmacia, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Valencia, Spain.
Fabio FerriniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Sara SalucciInstitute of Oncology Research, Bellinzona, Switzerland.
Michela BattistelliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.ORCID https://orcid.org/0000-0003-4028-0652
Sabrina BurattiniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Francesca LuchettiDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.ORCID https://orcid.org/0000-0002-8225-3129
Maria Gemma NasoniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
Giosuè AnnibaliniDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.ORCID https://orcid.org/0000-0002-6914-4905
Matteo MicucciDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.ORCID https://orcid.org/0000-0003-3525-1531
Federico GianfantiUniversità della Svizzera Italiana, Lugano, Switzerland.
Piero SestiliDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.ORCID https://orcid.org/0000-0001-9412-1660
Mar LarrosaMAS Microbiota Group, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odón, Spain.
Elena BarbieriDepartment of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we describe the effect of cocoa polyphenol extract (CPE, from flavanols-rich cocoa) on myogenic differentiation in murine myoblasts (C2C12 cells) exposed to H

Indexed as

CacaoMitochondriaMuscle DevelopmentMyoblastsOxidative StressPlant ExtractsPolyphenolsRegenerationAnimalsCell DifferentiationCell LineCell SurvivalHydrogen PeroxideMiceMuscle Fibers, SkeletalHydrogen PeroxidePlant ExtractsPolyphenolsC2C12 cellsmitochondriamuscle regenerationnutraceuticalsoxidative stress

Identifiers

PMID39614764
PMCPMC11842948

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.